Polyarteritis nodosa: a clinical case report
DOI: 10.32364/2587-6821-2026-10-3-9
Polyarteritis nodosa: a clinical case report
I.S. Svintsitskaya1, V.A. Likhodkin2, E.S. Ambartsumov3, D.N. Yanishevsky1
1Military Medical Academy, St. Petersburg, Russian Federation
2A.A. Vishnevsky National Medical Research Center of High Medical Technologies of the Ministry of Defense of Russia, Krasnogorsk, Russian Federation
3MMC VT LLC, Leningrad Region, Yukkovskoye Rural Settlement, Beloostrov Clinic Territory, Russian Federation
Polyarteritis nodosa (PAN) is a rare systemic necrotizing vasculitis characterized by the predominant involvement of medium- and small-caliber arteries, resulting in ischemic, inflammatory, and thrombotic changes affecting various organs and tissues. The disease is notable for its marked clinical polymorphism, which frequently leads to diagnostic difficulties, delayed diagnosis verification, and repeated revision of clinical hypotheses at different stages of patient follow-up.
This article presents a clinical case of a young patient with childhood-onset disease, a relapsing course, prominent cutaneous, articular, and neurological manifestations, as well as high laboratory inflammatory activity. A retrospective analysis was performed, encompassing anamnestic data, clinical examination findings, and laboratory and instrumental investigation results. Particular attention was given to the evolution of the clinical presentation, dynamics of inflammatory activity markers, development of complications, peripheral nervous system involvement, and response to the administered therapy.
The presented case illustrates the importance of comprehensive clinicopathological assessment, timely diagnostic verification, and early initiation of pathogenetic immunosuppressive therapy. Current approaches to the diagnosis, treatment, prognostic evaluation, relapse prevention, and multidisciplinary management of patients with polyarteritis nodosa are discussed.
Keywords: polyarteritis nodosa, systemic vasculitis, necrotizing arteritis, cutaneous vasculitis, glucocorticosteroids, cyclophosphamide.
For citation: Svintsitskaya I.S., Likhodkin V.A., Ambartsumov E.S., Yanishevsky D.N. Polyarteritis nodosa: a clinical case report. Russian Medical Inquiry. 2026;10(3):168–173 (in Russ.). DOI: 10.32364/2587-6821-2026-10-3-9
About the authors:
Irina S. Svintsitskaya — C. Sc. (Med.), Associate Professor of the Department of Faculty Internal Medicine, Military Medical Academy; 6, Akademika Lebedeva str., St. Petersburg, 194044, Russian Federation; ORCID iD 0000-0002-1317-8276
Vadim A. Likhodkin — Senior Resident of the Rheumatology Department, A.A. Vishnevsky National Medical Research Center of High Medical Technologies of the Ministry of Defense of Russia; 1, Novy Settlement, Krasnogorsk, 143420, Russian Federation; ORCID iD 0000-0001-7651-7709
Eduard S. Ambartsumov — rheumatologist, MMC VT LLC; Build. 1, Block 1, Beloostrov Clinic Territory, Yukkovskoye Rural Settlement, Vsevolozhsky District, Leningrad Region, 188632, Russian Federation; ORCID iD 0000-0003-1505-3263
Daniil N. Yanishevsky — Medical Cadet, Faculty of Physician Training, Military Medical Academy, Ministry of Defense of the Russian Federation; 6, Akademika Lebedeva str., St. Petersburg, 194044, Russian Federation; ORCID iD 0009-0007-3723-6286
Contact information: Irina S. Svintsitskaya, e-mail: sonirinadoc@mail.ru
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 16.02.2026.
Revised 05.03.2026.
Accepted 27.03.2026.
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