Modern Methods of Diagnosis and Treatment of Takayasu arteritis
DOI: 10.32364/2587-6821-2025-9-3-3
D.A. Baldanova
City Polyclinic No. 23, St. Petersburg, Russian Federation
Takayasu arteritis (TA) is a rare systemic vasculitis characterized by chronic inflammation of the aorta and its main branches. Despite major advances in the pathogenesis studies, diagnosis and treatment are still complicated interdisciplinary issues of modern medicine. The paper highlights a comprehensive analysis of advanced approaches to diagnosis, therapy and monitoring of TA based on systematization of scientific data. Early diagnosis by modern imaging methods such as fluorodeoxyglucose positron emission tomography combined with computed tomography, MR angiography, and contrast-enhanced ultrasound, is a key factor of successful patient management. The treatment represents an individual approach using combined immunosuppressive therapy (including glucocorticosteroids and disease-modifying anti-inflammatory drugs). The therapeutic prospects are associated with personalized medicine, targeted drug development and improved diagnostic criteria.
Keywords: Takayasu's disease, Takayasu arteritis, systemic vasculitis, diagnosis, immunosuppressive therapy, personalized medicine, CT angiography, nonspecific aortoarteritis.
For citation: Baldanova D.A. Modern Methods of Diagnosis and Treatment of Takayasu arteritis. Russian Medical Inquiry. 2025;9(3):162–166 (in Russ.). DOI: 10.32364/2587-6821-2025-9-3-3
About the author:
Daria A. Baldanova — Cardiovascular Surgeon, Ultrasound Doctor, City Polyclinic No. 23; 17, Kosinova str., St. Petersburg, Russian Federation, 198095; ORCID iD 0009-0009-5525-9072
Contact information: Daria A. Baldanova, e-mail: biris92@mail.ru
Financial Disclosure: the author does not have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 27.03.2025.
Revised 10.04.2025.
Accepted 17.04.2025.
2. Егорова О.Н., Тарасова Г.М., Койлубаева Г.М. и др. Современные подходы к терапии артериита Такаясу. Современная ревматология. 2024;18(1):101–108. DOI: 10.14412/1996-7012-2024-1-101-108Egorova O.N., Tarasova G.M., Koilubaeva G.M. et al. Modern approaches to the therapy of Takayasu arteritis. Modern Rheumatology Journal. 2024;18(1):101–108 (in Russ.). DOI: 10.14412/1996-7012-2024-1-101-108
3. Rutter M., Bowley J., Lanyon P.C. et al. A Systematic Review and Meta-Analysis of the Incidence Rate of Takayasu Arteritis. Rheumatology (Oxford). 2021;60(11):4982–4990. DOI: 10.1093/rheumatology/keab406
4. Saadoun D., Bura-Riviere A., Comarmond C. et al. French recommendations for the management of Takayasu's arteritis. Orphanet J Rare Dis. 2021;16(3):311. DOI: 10.1186/s13023-021-01922-1
5. Terao C. Revisited HLA and non-HLA genetics of Takayasu arteritis--wh ere are we? J Hum Genet. 2016;61(1):27–32. DOI: 10.1038/jhg.2015.87
6. Carmona F.D., Coit P., Saruhan-Direskeneli G. et al. Analysis of the common genetic component of large-vessel vasculitis through a meta-Immunochip strategy. Sci Rep. 2017;7:43953. DOI: 10.1038/srep43953
7. Terao C., Yoshifuji H., Kimura A. et al. Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population. Am J Hum Genet. 2013;93(2):289–297. DOI: 10.1016/j.ajhg.2013.05.024
8. Гончарова Н.С., Самохвалова М.В., Пахомов А.В. и др. Артериит Такаясу. Обзор литературы. Артериальная гипертензия. 2013;19(6):478–476. DOI: 10.18705/1607-419X-2013-19-6-478-476Goncharova N.S., Samokhvalova M.V., Pakhomov A.V. et al. Takayasu Arteritis: A Review. Arterial Hypertension. 2013;19(6):478–476 (in Russ.) DOI: 10.18705/1607-419X-2013-19-6-478-476
9. Смитиенко И.О., Атясова Е.В., Новиков П.И. Методы визуализации сосудистого воспаления при артериите Такаясу. РМЖ. 2017;7:442–445.Smitienko I.O., Atyasova E.V., Novikov P.I. Methods of vascular inflammation imaging in Takayasu arteritis. RMJ. 2017;7:442–445 (in Russ.).
10. Grayson P.C., Ponte C., Suppiah R. et al. 2022 American College of Rheumatology/EULAR Classification Criteria for Takayasu Arteritis. Arthritis Rheumatol. 2022;74(12):1872–1880. DOI: 10.1002/art.42324
11. Grayson P.C., Cuthbertson D., Carette S. et al. New features of disease after diagnosis in 6 forms of systemic vasculitis. J Rheumatol. 2013;40:1905–1912. DOI: 10.3899/jrheum.121473
12. Суванов Б.С., Шалин В.В., Вирясова А.А. и др. Артериит Такаясу — актуальная проблема современной ревматологии (обзор литературы). Сибирское медицинское обозрение. 2022;1:5–14. DOI: 10.20333/25000136-2022-1-5-14Suvanov B.S Shalin V.V Viryasova A.A. et al. Takayasu arteritis — an actual problem of modern rheumatology (literature review). Siberian Medical Review. 2022;1:5–14 (in Russ.). DOI: 10.20333/25000136-2022-1-5-14
13. Eshet Y., Pauzner R., Goitein O. et al. The limited role of MRI in long-term follow-up of patients with Takayasu's arteritis. Autoimmun Rev. 2011;(11):132–136. DOI: 10.1016/j.autrev.2011.09.002
14. Schmidt W.A. Imaging in vasculitis. Best Pract Res Clin Rheumatol. 2013;27:107–118. DOI: 10.1016/j.berh.2013.01.001. PMID: 23507061
15. Keser G., Aksu K. What is new in management of Takayasu arteritis? La Presse Médicale. 2017;46:e229–e235. DOI: 10.1016/j.lpm.2016.11.033
16. Ohigashi H., Haraguchi G., Konishi M. et al. Improved prognosis of Takayasu arteritis over the past decade. Circ J. 2012;76(4):1004–1011. DOI: 10.1253/circj.cj-11-1108
17. Maz M., Chung S.A., Abril A. et al. American college of rheumatology/vasculitis foundation guideline for the management of giant cell arteritis and Takayasu Arteritis. Arthritis Rheumatol. 2021;73(8):1349–1365. DOI: 10.1002/art.41774
18. Loricera J., Blanco R., Castaneda S., Humbría A. et al. Tocilizumab in refractory aortitis: study on 16 patients and literature review. Clin Exp Rheumatol. 2014;(32):79–89. PMID: 24854377
19. Shi G., Hua M., Xu Q., Ren T. Resveratrol improves treatment outcome and laboratory parameters in patients with Takayasu arteritis: A randomized double-blind and placebo-controlled trial. Immunobiology. 2017;222(2):164–168. DOI: 10.1016/j.imbio.2016.10.008
20. Dejaco C., Ramiro S., Duftner C. et al. EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice. Ann Rheum Dis. 2018;77(5):636–643. DOI: 10.1136/annrheumdis-2017-212649

This work is licensed under a Creative Commons «Attribution» 4.0 License.
















