Acute respiratory infections in children: a rational approach to therapy
S.V. Nikolaeva1, A.V. Gorelov1,2
1Central Research Institute of Epidemiology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow
2Sechenov University, Moscow
In recent years, there is a high incidence of acute respiratory infections (ARI) among children, which is up to 80% in the ARI morbidity patterns in the overall population. Despite the viral ARI (ARVI) prevalence, there is an unreasonably high (up to 70% and higher in different countries) prescription rate of antibiotic drugs (ABDs) in uncomplicated ARVI by primary care physicians. In this regard, the issues of bacterial infection pathogens’ resistance to ABDs become of vital importance, which necessitates an approaches revision to the ABDs use: their unjustified use cancellation, especially in children with uncomplicated ARVI, drug and regimen choice optimization. At the same time, the ABDs prescription significance remains in ARI complications, rhinosinusitis, pneumonia, otitis, prolonged bronchitis in children as well and etc. ABDs may serve as a frontline drug for local (inhaled) administration such as Fluimucil®-antibiotic IT which impacts directly to the source of infection with its fast therapeutic effect achievement, without adverse events, peculiar to the systemic ABDs.
Keywords: antibiotic therapy, children, therapy, ARI, Fluimucil-antibiotic IT.
For citation: Nikolaeva S.V., Gorelov A.V. Acute respiratory infections in children: a rational approach to therapy. RMJ. Medical Review. 2019;3:61–63.
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2. Горелов А.В., Швец Е.Ю., Кондратьева Т.Ю. и др. Клинические особенности бокавирусной инфекции у детей. Инфекционные болезни. 2008; 6(4):11–16. [Gorelov A.V., Shvets E.Yu., Kondrat’eva T.Yu. et al. The Clinical features bocavirus infection in children. Infectious disease. 2008;6(4):11–16 (in Russ.)].
3. Appak Ö., Duman M., Belet N., Sayiner A.A. Viral respiratory infections diagnosed by multiplex polymerase chain reaction in pediatric patients. J Med Virol. 2019;91(5):731–737. DOI: 10.1002/jmv.25379 [Epub ahead of print].
4. Martínez-Roig A., Salvadó M., Caballero-Rabasco M.A. et al. Viral coinfection in childhood respiratory tract infections. Bronconeumol. 2015;51(1):5–9.
5. Fillatre A., François C., Segard C. et al. Epidemiology and seasonality of acute respiratory infections in hospitalized children over four consecutive years (2012–2016). J Clin Virol. 2018;102:27–31. DOI: 10.1016/j.jcv.2018.02.010
6. Jain S., Williams D.J., Arnold S.R. et al. Community-acquired pneumonia requiring hospitalization among U.S. children. N Engl J Med. 2015; 372(9):835–845.
7. Геппе Н.А., Дронов И.А., Колосова Н.Г. Эффективность применения тиамфеникола глицинат ацетилцистеината при острых бронхитах у детей. РМЖ. 2016;24(6):386–390. [Geppe N.A., Dronov I.A., Kolosova N.D. Efficacy of thiamphenicol glycinate acetylcysteine in acute bronchitis in children. RMJ. 2016;24(6):386–390 (in Russ.)].
8. Craven V., Everard M.L. Protracted bacterial bronchitis: reinventing an old disease. Arch Dis Child. 2013;98(1):72–76.
9. McCullough A.R., Pollack A.J., Plejdrup Hansen M. et al. Antibiotics for acute respiratory infections in general practice: comparison of prescribing rates with guideline recommendations. Med J Aust. 2017;207(2):65–69.
10. Gerber J.S., Prasad P.A., Russell Localio A. et al. Variation in antibiotic prescribing across a pediatric primary care network. J Pediatric Infect Dis Soc. 2015;4:297–304.
11. Shin S.M., Shin J.Y., Kim M.H. et al. Prevalence of antibiotic use for pediatric acute upper respiratory tract infections in Korea. J Korean Med Sci. 2015;30(5):617–624.
12. Bozic B., Bajcetic M. Use of antibiotics in paediatric primary care settings in Serbia. Arch Dis Child. 2015;100:966–969.
13. Maltezou H.C., Dedoukou X., Asimaki H. et al. Consumption of antibiotics by children in Greece: a cross-sectional study. Int J Pediatr Adolesc Med. 2017;4(3):108–111.
14. Рачина С.А., Козлов Р.С., Таточенко В.К. и др. Практика лечения острых респираторных инфекций у детей в амбулаторно-поликлинических учреждениях РФ: результаты многоцентрового фармакоэпидемиологического исследования. Клиническая фармакология и терапия. 2016;25(2):20–27. [Rachina S.A., Kozlov R.S., Tatochenko V.K. et al. Practice of treatment of acute respiratory infections in children in the outpatient clinics of the Russian Federation: results of a multicenter pharmacoepidemiological study. Clinical pharmacology and therapy. 2016;25(2):20–27 (in Russ.)].
15. Drago L., De Vecchi E., Fassina M.C. Comparative in vitro activity of thiamphenicol-glycinate and thiamphenicol-glycinate-acetylcysteinate and other antimicrobials against respiratory pathogens. Arzneimittelforschung. 2001;51(4):315–324.
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