Probiotics administration in the prevention of seasonal acute respiratory infection
T.A. Ruzhentsova1, D.A. Abdrashitov1, N.A. Meshkova2, A.V. Gorelov1,2
1Central Research Institute of Epidemiology of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow
2Sechenov University, Moscow
The article presents the basic information about the role of bifidobacteria and lactobacilli in the immune response formation in children and adults. The article also examines previously published and in-house data on the study results confirming the reduction in the acute respiratory infection morbidity during the probiotics administration in different age groups. In can be concluded that in order to reduce the number of seasonal infectious disease episodes in different age groups, it is necessary to use probiotics according to numerous data summarization. Lactobacilli and bifidobacteria are permanent necessary representatives of the human physiological microbiota, which currently needs to be actively supported. However, it is necessary to take into account the known data on the properties of one or another strain and the dosage, which will be enough to obtain the desired result, when choosing the probiotic composition. Currently, 1×109 CFU — is a necessary amount of bacteria cultures. The examination shows a significant effect of complex probiotic composition on the seasonal respiratory infection frequency and severity. The most successful combination of probiotics for seasonal morbidity prevention in childhood is: Streptococcus thermophilus + Lactobacillus paracasei ssp. paracasei + Bifidobacterium animalis ssp. lactis, which is contained in a specially created dosage form for kids — FlorOK® Baby. It should also be recommended for the microflora imbalance correction, which is observed in the majority of children today, as it entails frequent acute respiratory infections. This drug is safe, effective and especially important for children attending kindergartens and schools according to the available study results. A complex adequate physiological immune protection is formed both in a child and an adult, which significantly reduces the body’s susceptibility to infectious diseases when using a specially selected probiotic composition.
Keywords: Bifidobacterium BB-12, Lactobacillus acidophilus, Lactobacillus paracasei, Streptococcus thermophilus, Bifidobacterium, immunity, Lactobacillus, acute respiratory diseases.
For citation: Ruzhentsova T.A., Abdrashitov D.A., Meshkova N.A., Gorelov A.V. Probiotics administration in the prevention of seasonal acute respiratory infection. RMJ. Medical Review. 2019;3:26–28.
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2. Педиатрия. Национальное руководство. Краткое издание / под ред. А.А. Баранова. М.: ГЭОТАР-Медиа; 2015. [Pediatrics. National leadership. Short edition / ed. A.A. Baranov. M.: GEOTAR-Media; 2015 (in Russ.)].
3. Valeur N., Engel P., Carbajal N. et al. Colonization and Immunomodulation by Lactobacillus reuteri ATCC 55730 in the Human Gastrointestinal Tract. Applied and Environmental Microbiology. 2004;70(2):1176–1181. DOI: 10.1128/AEM.70.2.1176-1181.2004.
4. Jensen H., Grimmer S., Naterstad K., Axelsson L. In vitro testing of commercial and potential probiotic lactic acid bacteria. International Journal of Food Microbiology. 2010;2012(153):216–222.
5. Ouwehand A., Isolauri E., Salminen S. The role of intestinal microflora for development of the immune system in early childhood. Eur. J. Nutr. 2002;41:132–137.
6. Yan F., Polk D.B. Probiotic bacterium prevents cytokine-induced apoptosis in intestinal epithelial cells. J. Biol. Chem. 2002;277:50959–50965.
7. Smits H.H., Engering A., van Der K.D. et al. Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin . J. Allergy Clin. Immunol. 2005;115:1260–1267. DOI: 10.1016/j.jaci.2005.03.036.
8. Versalovi J., Hemarajata P. Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation. Therapeutic Advances in Gastroenterology, 2013;6(1):39–51. DOI: 10.1177/1756283X12459294.
9. Nova E., Viadel B., Wärnberg J. et al. Beneficial effects of a synbiotic supplement on self-perceived gastrointestinal well-being and immunoinflammatory status of healthy adults . J Med Food. 2011;14(1–2):79–85. DOI: 10.1089/jmf.2008.0328.
10. Corsello G., Carta M., Marinello R. et al. Preventive Effect of Cow’s Milk Fermented with Lactobacillus paracasei CBA L74 on Common Infectious Diseases in Children: A Multicenter Randomized Controlled Trial. Nutrients. 2017;9(7):Е669. DOI: 10.3390/nu9070669.
11. Belkacem N., Serafini N., Wheeler R. et al. Lactobacillus paracasei feeding improves immune control of influenza infection in mice. PLoS One. 2017;12(9):e0184976.
12. Ringel-Kulka T., Kotch J.B., Jensen E.T. et al. Randomized, double-blind, placebo-controlled study of synbiotic yogurt effect on the health of children. J Pediatr. 2015;166(6):1475–1481. DOI: 10.1016/j.jpeds.2015.02.038.
13. Čitar M., Hacin B., Tompa G. et al. Human intestinal mucosa-associated Lactobacillus and Bifidobacterium strains with probiotic properties modulate IL-10, IL-6 and IL-12 gene expression in THP-1 cells. Benef Microbes. 2015;6:325–336. DOI: 10.3920/BM2014.0081.
14. Lee A., Lee Y.J., Yoo H.J. et al. Consumption of Dairy Yogurt Containing Lactobacillus paracasei ssp. paracasei, Bifidobacterium animalis ssp. lactis and Heat-Treated Lactobacillus plantarum Improves Immune Function Including Natural Killer Cell Activity. Nutrients. 2017;9(6):558. DOI: 10.3390/nu9060558.
15. Leyer G.J., Li S., Mubasher M.E. et al. Probiotic effects on cold and influenza-like symptom incidence and duration in children. Pediatrics. 2009;124(2):e172–e179. DOI: 10.1542/peds.2008-2666.
16. Руженцова Т.А. Роль пробиотиков в формировании иммунитета. Лечащий врач. 2018;4:27–30. [Ruzhentsova T.A. The role of probiotics in the formation of immunity. Attending doctor. 2018;4:27–30 (in Russ.)].
17. Усенко Д.В. Антибиотик-индуцированные изменения микробиома желудочно-кишечного тракта и их коррекция. РМЖ. 2018;2(11):96–99. [Usenko D.V. Antibiotic-induced changes in the microbiome of the gastrointestinal tract and their correction. RMJ. 2018;2(11):96–99 (in Russ.)].
18. Мунблит Д.Б., Корсунский И.А. Про- и пребиотики в профилактике и лечении аллергических заболеваний. РМЖ. 2016;6:354–357. [Munblit D.B., Korsunsky I.A. Pro- and prebiotics in the prevention and treatment of allergic diseases. RMJ. 2016;6:354–357 (in Russ.)].
19. Калюжин О.В. Пробиотики как современные средства укрепления противоинфекционной иммунной защиты: миф или реальность? РМЖ. 2012;28:1395. [Kaluzhin O.V. Probiotics as modern means of strengthening anti-infective immune defenses: a myth or a reality? RMJ. 2012;28:1395 (in Russ.)].
20. Масчан А.А., Ковалева Л.Г., Пашанов Е.Д., Румянцев А.Г. Применение препарата элтромбопаг для лечения иммунной тромбоцитопении. РМЖ. 2010;15:944. [Maschan A.A., Kovaleva L.G., Pashanov E.D., Rumyantsev A.G. Use of the drug Eltrombopag for the treatment of immune thrombocytopenia. RMJ. 2010;15:944 (in Russ.)].
21. Свистушкин В.М., Волкова К.Б. Современное состояние проблемы респираторного папилломатоза гортани. РМЖ.2015;23:1377–1380. [Svistushkin V.M., Volkova K.B. The current state of the problem of respiratory papillomatosis of the larynx. RMJ. 2015;23:1377–1380 (in Russ.)].
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