Treatment of childhood ovarian germ cell tumors: historical review
I.V. Nechushkina1,2, V.M. Nechushkina1,3, E.I. Boichenko1,2, N.A. Susuleva1,2, A.B. Ryabov4, A.P. Kazantsev1, P.A. Kerimov1, M.I. Nechushkin1, M.A. Rubanskii1
1N.N. Blokhin National Medical Research Center of Oncology, Moscow
2Russian Medical Academy of Continuous Professional Education, Moscow
3Pirogov Russian National Research Medical University, Moscow
4National Medical Research Radiological Center, Moscow
Ovarian germ cell tumors are the most common pathology in girls among malignant lesions. The paper describes the history of different treatment modalities for this pathology. Emphasis is placed on the surgical treatment approaches change of children with ovarian germ cell tumors. Clinical features of ovarian germ cell tumors, the disease progression peculiarity in the abdominal cavity, were revealed in the studies of recent years. Ovarian germ cell tumor pattern consists of the peritoneal progression and liver injury. The ascites presence is an early and important sign of tumor recurrence. In terms of the ovarian germ cell tumor morphological structure, the diverse prognosis was noted. Chemotherapy application with platinum-based drugs has significantly improved the therapy results with minimal surgical intervention — oophorectomy on the lesion side. Such surgical treatment approach allowed to preserve the possibility of proper sexual development and fertility preservation, which significantly improved the quality of life in cured patients.
Keywords: germ cell tumors, ovarian tumors, conservative surgery, pediatric oncology.
For citation: Nechushkina I.V., Nechushkina V.M., Boichenko E.I. et al. Treatment of childhood ovarian germ cell tumors: historical review. RMJ. Medical Review. 2019;3:24–25.
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13. Billmire D.F., Cullen J.W., Frederick J.R. et al. Surveillance after initial surgery for pediatric and adolescent girls with stage I ovarian germ cell tumors: report from the Chidren’s Oncology Group. J Clin Oncol. 2014;32(5):465–470. DOI: 10.1200/JCO.2013.51.1006.
2. Kurman R.J., Norris H.J. Endodermal sinus tumor of ovary. A clinical and pathologic analysis of 71 cases. Cancer. 1976;38(6):2404–2419. (Electronic resource). URL: https://www.sciencedirect.com/science/artical (access date: 12.17.2018).
3. Kosloske A.M., Favara B.E., Hays T. et al. Management of immature teratoma of the ovary in children by conservative resection and chemotherapy. J Pediatr Surg. 1976;11(5):839–846. (Electronic resource). URL: https://www.sciencedirect.com/science/artical (access date: 12.10.2018).
4. Wollner N., Exelby P.R., Woodruff J.M. et al. Malignant ovarian tumors in childhood: prognosis in relation to initial therapy. Cancer. 1976;37:1953–1964. (Electronic resource). URL: https://www.sciencedirect.com/science/artical (access date: 12.10.2018).
5. Piver M.S., Sinks L., Barlow J.J., Tsukada Y. Five-year remissions of metastatic solid teratoma of the ovary. Cancer. 1976;38(2):987–993. (Electronic resource). URL: https://www.sciencedirect.com/science/artical (access date: 12.10.2018).
6. Einhorn L.H., Donohue J.P. Improved chemotherapy in disseminated testicular cancer. J Urol. 1977;117:65–69. (Electronic resource). URL: https://www.sciencedirect.com/science/artical (access date: 12.10.2018).
7. Cushing B., Giller R., Cullen J.W. et al. Randomized comparison of combination chemotherapy with etoposide, bleomycin and either high-dose or standard-dose cisplatin in children and adolescents with high-risk malignant germ cell tumors: a pediatric intergroup study — Pediatric Oncology Group 9049 and Children Cancer Group 8882. J Clin Oncol. 2004;22:2691–2700. DOI:10.1200/JCO.2004.08.015.
8. Baranzelli M.S., Bouffet E., Quintana E. et al. Non-seminomatous ovarian germ cell tumors in children. Eur J Cancer. 2000;36:376–383. (Electronic resource). URL: https://www.sciencedirect.com/science/artical (access date: 12.10.2018).
9. Culine S., Lhomme C., Michel G. et al. Is there a role for second-look laparotomy in the management of malignant germ cell tumors of the ovary? Experience at Institut Gustave Roussy. J Surg Oncol. 1996;62:40–45. (Electronic resource). URL: https://www.sciencedirect.com/science/artical (access date: 12.13.2018).
10. Rogers P.C., Olson T.A., Cullen J.W. et al. Treatment of children and adolescent with stage II testicular and stage I and II ovarian malignant germ cell tumors: A Pediatric Intergroup Study — Pediatric Oncology Group 9048 and Children’s Cancer Group 8891. J Clin Oncol. 2004;22:3563–3569. DOI: 10.1200/JCO.2004.01.006.
11. Hale G.A., Marina N.M., Jones-Wallace D. et al. Late effects of treatment for germ cell tumors during childhood and adolescence. J Pediatr Hematol Oncol. 1999;21:115–122. (Electronic resource). URL: https://www.sciencedirect.com/science/artical (access date: 12.10.2018).
12. Travis L.B., Beard C., Allan J.M. et al. Testicular cancer survivorship: research strategies and recommendations. J Natl Cancer Inst. 2010;102:1114–1130. DOI: 10.1093/jnci/djq216.
13. Billmire D.F., Cullen J.W., Frederick J.R. et al. Surveillance after initial surgery for pediatric and adolescent girls with stage I ovarian germ cell tumors: report from the Chidren’s Oncology Group. J Clin Oncol. 2014;32(5):465–470. DOI: 10.1200/JCO.2013.51.1006.
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