Hyaluronic acid usage in patients with dry eye syndrome due to meibomian gland dysfunction
Razhko Yu.I.

The Republican Research Center of Radiation Medicine and Human Ecology, Gomel, Belarus

Purpose 
To present clinical experience of 0.15% hyaluronic acid (HA) usage in women with dry eye syndrome (DES) due to meibomian gland dysfunction after hysterectomy . 
Material and methods. 33 women (66 eyes) after hysterectomy with DES, aged 39 to 56 years (mean age: 47.58±5.01). HA instillation was performed 3 times a day. Сalculation of body mass index andmenopausal Kupperman index, serum sex and pituitary hormones levels measurement; were performed. Ophthalmic examination included evaluation of the eye surface, refractometry, pneumotonometry, biomicroscopy, noncontact ophthalmoscopy, corneal endothelial microscopy. Meibomian indexes, tear production, tear film stability and ocular surface staining were also assessed. Control examinations were performed in 1 and 6 months. 
Results. Strong positive correlation Awas revealed between natomical and functional changes of the ocular surface occlusal index and the index of eyelids deformation and the severity of climacteric syndrome and estrogen levels. Treatment with HA led to decrease of complaints typical for DES, better results of ocular surface staining and tear film stability tests Allergic reactions were not observed. Patients with mild DES used one HA bottle for a long time.
Conclusion. The use of thixotropic HA drops in women with estrogen deficiency syndrome and different stages of meibomian glands dysfunction has significant positive therapeutic effect and can be used as pathogenetic treatment of DES after hysterectomy.

Key words: hysterectomy, estrogen deficiency syndrome, dry eye syndrome, hyaluronic acid. 

For citation: Razhko Yu.I. Hyaluronic acid usage in patients with dry eye syndrome due to meibomian gland dysfunction // RMJ. Clinical ophthalmology. 2016. № 2. P. 82–89.