Optic nerve sheath diameter in chronic myeloproliferative disorders
DOI: 10.32364/2311-7729-2024-24-2-2
E.M. Yunusova, T.R. Mukhamadeev, B.A. Bakirov
Bashkir State Medical University, Ufa, Russian Federatio
Aim: to evaluate the optic nerve sheath diameter (ONSD) in patients with chronic myeloproliferative disorders (MPD) using ultrasound (US).
Patients and Methods: the study included 32 patients (64 eyes) with established chronic MPD and 28 gender- and age-matched healthy volunteers (56 eyes) without chronic MPD. Several patients had a history of cardiovascular diseases, which may be related to long-term use of specific target therapy. All patients underwent a comprehensive eye examination, which included eye and orbit ultrasonography, as well as laboratory tests such as complete blood count (CBC) and coagulation test.
Results: the majority (81.3%) of patients had either unilateral or bilateral increases in ONSD. Furthermore, ONSD was found to be significantly greater in patients with chronic MPD who also had increased white blood cell count, platelet count, and fibrinogen levels, as well as decreased hemoglobin levels, compared to those without a history of chronic MPD. The correlation was stronger in patients with chronic MPD than in the control group. Correlations were found between ONSD and all studied hematologic parameters. A moderate negative correlation was found between ONSD and hemoglobin, a weak positive correlation between ONSD and WBC count, and a moderate positive correlation between ONSD and platelet and fibrinogen in patients with chronic MPD.
Conclusion: an increase in ONSD was detected by eye and orbit US in patients with chronic MPD who also had hematologic abnormalities. This symptom may be an early sign of vascular complications secondary to long-term specific treatment. An increase in ONSD can illustrate increased intracranial pressure. For patients with chronic MPD, it is recommended to have more detailed follow-up to prevent vision loss and life-threatening complications in the central nervous system due to disease progression, in particular, those with an increase in ONSD.
Keywords: chronic myeloproliferative diseases, optic nerve sheath diameter, ultrasound, blood rheology, vascular complications, chronic myeloid leukemia, true polycythemia, essential thrombocythemia, intracranial hypertension.
For citation: Yunusova E.M., Mukhamadeev T.R., Bakirov B.A. Optic nerve sheath diameter in chronic myeloproliferative disorders. Russian Journal of Clinical Ophthalmology. 2024;24(2):55–59 (in Russ.). DOI: 10.32364/2311-7729-2024-24-2-2.
About the authors:
Elvira M. Yunusova — in absentia postgraduate student of the Department of Ophthalmology with the Course of the Institute of Additional Professional Education, Bashkir State Medical University; 3, Lenin str., Ufa, 450008, Russian Federation; ORCID iD 0000-0002-4756-1687.
Timur R. Mukhamadeev — Dr. Sc. (Med.), Head of the Department of Ophthalmology with the Course of the Institute of Additional Professional Education, Bashkir State Medical University; 3, Lenin str., Ufa, 450008, Russian Federation; ORCID iD 0000-0003-3078-2464.
Bulat A. Bakirov — Dr. Sc. (Med.), Head of the Department of Hospital Therapy No. 2, Bashkir State Medical University; 3, Lenin str., Ufa, 450008, Russian Federation; ORCID iD 0000-0002-3297-1608.
Contact information: Elvira M. Yunusova, e-mail: zainullina16@mail.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 01.06.2023.
Revised 27.06.2023.
Accepted 20.07.2023.
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