Early dement cognitive impairments with debut at a young age: the possibilities of diagnosis and treatment
Kolokolov O.V., Maleina A.Yu., Kolokolova A.M.

Saratov State Medical University named after V.I.Razumovsky

The article discusses the urgent problem of timely diagnosis of early dement cognitive impairments (CIs), debuting at a young age. The criteria for clinical diagnosis, neuropsychological approaches, methods of neuroimaging and biomarkers that allow determining the type of CI and the etiology of the disease are listed. The most appropriate approach in complex situations is the referral of patients to clinics that specialize in CI diagnosis.
Data are presented on the relationship between sleep disorders, depression, systemic inflammation and CI. Attention is focused on the fact that correction of sleep disorders and depression in some cases allows to achieve restoration of cognitive functions.
It is stated that the treatment of early dement cognitive impairments, debuting at a young age, largely depends on the etiology of the disease. In some cases, the timely administration of etiotropic therapy allows recovery of impaired functions, in others it may not be effective.
The authors provide their own data on the use of the drug Divaza in patients younger than 65 years with chronic cerebrovascular disease (CVB). The use of the drug Divaza, which has the nootropic, vasoactive and antioxidant action, in combination with basic therapy, allows to restore the quality of night sleep and reduce the severity of moderate cognitive impairments.

Key words: cognitive functions, dementia, mild cognitive impairments, dementia with debut at a young age, neuroimaging, biomarkers, S100 protein, Divaza.
For citation: Kolokolov O.V., Maleina A.Yu., Kolokolova A.M. Early dement cognitive impairments with debut at a young age: the possibilities of diagnosis and treatment // RMJ.  2017. № 14. P.1014 –1020.