Mast cell population in the testicle during pathospermia
DOI: 10.32364/2587-6821-2022-6-4-195-199
N.G. Kulchenko
Peoples’ Friendship University of Russia (RUDN University), Moscow, Russian Federation
Nowadays, male and female infertility factors can cause infertile marriage with the same frequency. It is known that the causes of male infertility can be varicocele, genetic disorders, endocrine diseases, congenital pathologies, injuries and inflammatory diseases. Despite a sufficient set of diagnostic techniques, the form of male infertility remains unidentified (idiopathic) in 1/3 of men. At present, the role of mast cells (MC) in the development of chronic pelvic pain syndrome, chronic prostatitis, and chronic epididymitis are shown. However, the role of MC in the formation of male infertility still remains open. The article presents a clinical case of a male patient with primary infertility and non-obstructive azoospermia, who underwent a testicular biopsy to identify the causes of infertility. Morphological examination of the biopsy specimen revealed the MC population in the testicular interstitium. This particular finding allows to explain the presence of fibro sis in the connective tissue and the epithelium of convoluted seminiferous tubules in this patient. The revealed testicular fibrosis led to a permeability disorder of the blood-testis barrier and a spermatogenic epithelial cell death, resulted in the development of azoospermia in the particular male patient.
Keywords: male infertility, pathospermia, spermatogenesis disorders, mast cells, fibrosis, azoospermia.
For citation: Kulchenko N.G. Mast cell population in the testicle during pathospermia. Russian Medical Inquiry. 2022;6(4):195–199 (in Russ.). DOI: 10.32364/2587-6821-2022-6-4-195-199.
Acknowledgements
The author is grateful to Dmitry A. Atyashkin, Dr. Sc. (Med.), Director of the Scientific and Educational Resource Center "Innovative Technologies of Immunophenotyping, Digital Spatial Profiling and Ultrastructural Analysis" of the Peoples’ Friendship University of Russia, for the technical edition.
About the author:
Nina G. Kulchenko — C. Sc. (Med.), urologist, ultrasound specialist, Associate Professor of the Department of Human Anatomy of the Medical Institute, Peoples’ Friendship University of Russia (RUDN University); 6 Miklukho-Maklaya str., Moscow, 117198, Russian Federation; ORCID iD 0000-0002-4468-3670.
Contact information: Nina G. Kulchenko, e-mail: kle-kni@mail.ru.
Financial Disclosure: no author has a financial or property interest in any material or method mentioned.
There is no conflict of interests.
Received 20.01.2022.
Revised 14.02.2022.
Accepted 14.03.2022.
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