Rare clinical case of Hageman disease in the patient of the cardiological department

Akhmedov V.A.¹, Shadevsky V.M.¹, Sudakova A.N.¹, Gaus O.V.1, Gudalov S.O.², Shustov A.V.<sup>2

1</sup> Omsk State Medical University
² “Clinical Cardiology Hospital”, Omsk

Hageman’s disease is an extremely rare disorder of hemostasis, characterized by a significant decrease in the activity of plasma blood coagulation factor XII. The presented case reports the identification of rare Hageman disease in the woman of 58 years old with cardiac pathology. The patient repeatedly admitted to the cardiology department for treatment of ischemic heart disease, arterial hypertension. During one of the visits, an elongation of the activated partial thromboplastin time (APTT) was revealed, which was the cause for further follow-up. Conducting the examination in the conditions of the hematological scientific center revealed a rare pathology of coagulation — Hageman’s disease, based on the absence of factor XII in the coagulogram, prolongation of the APTT and retardation of fibrinolysis. The feature of this case is that the disease has been asymptomatic for a long time, aggravating the course of cardiovascular pathology. Particularly interesting is the fact that the patient was found to have a complete absence of blood coagulation factor XII, whereas in previously published observations only the deficiency of this factor was described.

Key words: rare case, Hageman’s disease, absence of factor XII, coagulating blood system, hemostasis, coagulogram, APTT.
For citation: Akhmedov V.A., Shadevsky V.M., Sudakova A.N. et al. Rare clinical case of Hageman disease in the patient of the cardiological department // RMJ. 2018. № 6(I). P. 46–48.