Sarcopenia and inflammatory bowel diseases: pathogenetic mechanism and practical significance

Sarcopenia and inflammatory bowel diseases: pathogenetic mechanism and practical significance

G.R. Bikbavova, M.A. Livzan, D.V. Tikhonravova, N.S. Lisyutenko, A.E. Romanyuk

 Omsk State Medical University, Omsk 

Sarcopenia is a generalized, progressive loss of skeletal muscle mass, their strength and capacity, leading to a deteriorating of the life quality, an increase in the risk of falling, hospitalization and mortality. Initially, muscle mass loss was considered as a condition associated with age. Currently, there is growing interest in premature sarcopenia, which is observed in the setting of acute and chronic inflammatory processes, including inflammatory bowel diseases (IBD). However, there are limited data on sarcopenia in patients with IBD. Nevertheless, published studies indicate the association of sarcopenia with the disease activity, the need for surgical treatment and adverse postoperative outcomes. Sarcopenia occurs in 20—70% of patients with IBD. In recent years, the characteristics diagnosis of nutritional status disorders in patients with IBD has been undergoing changes due to the obesity spread. Sarcopenia in such patients may occur in the setting of obesity, remaining undiagnosed for a long time.

This article analyzes current information on the incidence of sarcopenia in patients with IBD, its effect on the disease course and the outcomes of surgical treatment.

Keywords: sarcopenia, inflammatory bowel diseases, nutritional status, sarcopenic obesity.

For citation: Bikbavova G.R., Livzan M.A., Tikhonravova D.V., Lisyutenko N.S., Romanyuk A.E. Sarcopenia and inflammatory bowel diseases: pathogenetic mechanism and practical significance. RMJ. 2023;5:39–42.