Study of the hormonal and metabolic condition association with senile asthenia syndrome among long-living persons

Study of the hormonal and metabolic condition association with senile asthenia syndrome among long-living persons

L.V. Machekhina¹, V.S. Ostapenko¹ , O.N. Tkacheva¹, I.Kh. Jumaniyazova², V.V. Erema², M.V. Ivanov², D.A. Kashtanova², A.V. Balashova¹, A.K. Ilyuschenko¹, E.S. Klyukina¹, A.M. Rumyantseva², V.S. Yudin², V.V. Makarov², A.A. Keskinov², S.M. Yudin², I.D. Strazhesko¹

 ¹Russian Gerontological Research and Clinical Center, Pirogov Russian National Research Medical University, Moscow

²Center for Strategic Planning of the Federal Medical Biological Agency of Russia, Moscow

 Aim: to study the association of hormonal and metabolic condition with senile asthenia syndrome in long-living persons.

Materials and Methods: a cohort of long-living persons was studied as part of a cross-sectional trial. An arbitrary sampling method was used. The search for participants was conducted with the involvement of social services, boarding houses for veterans of labor, gerontological centers and other geriatric services. For all study participants, during the visit of a doctor and a nurse, medical histories were taken, geriatric scales and questionnaires were filled out to identify the presence and severity of senile asthenia (SA), as well as blood samples were taken to assess lipid profile parameters, indicators of carbohydrate metabolism, hormones, and telomere length.

Results: a total of 3007 people who met the inclusion criteria were included in the study. Senile asthenia was detected in 627 out of 759 male patients (82.6%) and 2061 out of 2248 female patients (91.7%). The following parameters had a statistically significant feedback with SA: the level of 25-OH vitamin D (increase in the concentration of 25-OH vitamin D by 10 ng/mL lowered odds of having senile asthenia by 11% (95% CI [0.0001%, 21%])), apolipoprotein A1 (increase in the concentration of apolipoprotein A1 by 10 mg/dL lowered odds of having senile asthenia by 8% (95% CI [3%, 12%])), albumin (increase in albumin by 10 g/L lowered odds of having senile asthenia by 36% (95% CI [12%, 53%])) and free triiodothyronine (increase of free triiodothyronine by 2 pmol/L lowered odds of having senile asthenia by 37% (95% CI [8%, 57%])).

Conclusion: low levels of 25-OH vitamin D, apolipoprotein A1, free triiodothyronine and albumin can be considered markers associated with the presence of senile asthenia among long-living persons. The preventive value of correcting these indicators deserves further study.

Keywords: geriatrics, long-living persons, senile asthenia, biomarker, 25-OH vitamin D, apolipoprotein A1, triiodothyronine, albumin.

For citation: Machekhina L.V., Ostapenko V.S., Tkacheva O.N., Jumaniyazova I.Kh., Erema V.V., Ivanov M.V., Kashtanova D.A., Balashova A.V., Ilyuschenko A.K., Klyukina E.S., Rumyantseva A.M., Yudin V.S., Makarov V.V., Keskinov A.A., Yudin S.M., Strazhesko I.D. Study of the hormonal and metabolic condition association with senile asthenia syndrome among long-living persons. RMJ. 2023;5:32–38.