Intestinal microbiocenosis disorder: current aspects of terminology, clinical picture and prevention

V.V. Goloshubina, D.I. Trukhan, N.V. Bagisheva

Omsk State Medical University, Omsk

Bacterial flora in the gastrointestinal tract (GI) has a topical and systemic effect not only on the digestive organs but also on the entire body. Numerous studies have proved the pathogenetic association of the intestinal biocenosis state not only with GI diseases but also with pathological processes of other body organs and systems. At the same time, quantitative and qualitative changes in the normal intestinal microflora commonly occur as a result of various adverse events in humans and the development of various pathological conditions. In this review, the current aspects of terminology and clinical picture of intestinal microbiocenosis disorders are considered. Probiotics, prebiotics and synbiotics occupy an important place in the combination therapy of intestinal microbiocenosis disorders and clinical manifestations, associated with them. The review examines the main mechanisms of probiotic-host interaction, probiotics possibl e effects, and the requirements for them. Probiotics, prebiotics and synbiotics are used as the first-line treatment in the prevention of intestinal microbiocenosis disorders and associated possible metabolic shifts.

Keywords: intestinal microbiocenosis, dysbiosis, dysbacteriosis, clinical picture, prevention, probiotic, prebiotic, synbiotic, Bifidobacterium lactis, inulin, cholecalciferol.

For citation: Goloshubina V.V., Trukhan D.I., Bagisheva N.V. Intestinal microbiocenosis disorder: current aspects of terminology, clinical picture and prevention. RMJ. 2020;12:17–22.