Vitamin D deficiency in children with obesity: consequence or cause?
DOI: 10.32364/2587-6821-2022-6-9-516-522
E.V. Kanner1, M.L. Maksimov2,3, I.D. Kanner4, A.V. Gorelov1,5
1Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russian Federation
2Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuous Professional Education, Kazan, Russian Federation
3Pirogov Russian National Research Medical University, Moscow, Russian Federation
4Lomonosov Moscow State University, Moscow, Russian Federation
5I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Over the past decades it has become obvious that the prevalence of obesity and vitamin D deficiency is considered epidemic both in individual countries and worldwide. Pediatric obesity is a global problem. Regarding vitamin D, in addition to its role in bone health and calcium and phosphorus metabolism, its role in immune functions and in decreasing the risk of chronic illnesses has been considered. Vitamin D deficiency and excess body fat have mutual negative effects, resulting from metabolic processes that generate accumulation of inactive forms and decreased vitamin D bioavailability, in addition to decreased tissue secretion and sensitivity to insulin. As regards the supplementation of vitamin D in schoolchildren, especially in the risk groups which include obese adolescents, its doses should be higher than those routinely recommended for the prevention of hypovitaminosis D in the general population. It is necessary to include obese patients in a specific high-ris k group of vitamin D deficiency and measure their blood serum 25(OH)D level. In case of vitamin D insufficiency or deficiency it is essential to use high-dose cholecalciferol. However, one should remember that just losing a greater than 5% of baseline weight may improve vitamin D status in obese patients.
Keywords: obesity, children, adolescents, excess body weight, vitamin D deficiency, vitamin D, cholecalciferol.
For citation: Kanner E.V., Maksimov M.L., Kanner I.D., Gorelov A.V. Vitamin D deficiency in children with obesity: consequence or cause? Russian Medical Inquiry. 2022;6(9):516–522 (in Russ.). DOI: 10.32364/2587-6821-2022-6-9-516-522.
About the authors:
Ekaterina V. Kanner — Dr. Sc. (Med.), senior researcher of the clinical division of infectious diseases, Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; 3A, Novogireevskaya str., Moscow, 111123, Russian Federation; ORCID iD 0000-0003-3204-1846.
Maksim L. Maksimov — Dr. Sc. (Med.), chief external expert — clinical pharmacologist of the Ministry of Health of the Republic of Tatarstan; Head of the Department of Clinical Pharmacology and Pharmacotherapy, Kazan State Medical Academy — Branch of the Russian Medical Academy of Continuous Professional Education; 36, Butlerov str., Kazan, 420012, Russian Federation; Professor of the Department of Pharmacology, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117437, Russian Federation; ORCID iD 0000-0002-8979-8084.
Il’ya D. Kanner — 5-grade student of Lomonosov Moscow State University; 1, Leninskie Gory, Moscow, 119991, Russian Federation; ORCID iD 0000-0003-4632-0547.
Aleksandr V. Gorelov — Academician of the RAS, Dr. Sc. (Med.), Deputy director for Research, Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being; 3A, Novogireevskaya str., Moscow, 111123, Russian Federation; Professor of the Department of Childhood Diseases, I.M. Sechenov First Moscow State Medical University (Sechenov University); 8 Build. 2, Trubetskaya str., Moscow, 119991, Russian Federation; ORCID iD 0000-0001-9257-0171.
Contact information: Ekaterina V. Kanner, e-mail: ekanner@mail.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interests.
Received 02.08.2022.
Revised 25.08.2022.
Accepted 19.09.2022.
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