Patients with premature skin aging. Patient management and risk forecasting

Patients with premature skin aging. Patient management and risk forecasting

N.N. Potekaev^1,2, O.B. Borzykh³, E.I. Karpova¹, M.M. Petrova³, N.A. Schneider^3,4, D.V. Dmitrenko³, O.M. Demina¹, M.A. Zatolokina⁵, E.E. Timechko³ 

¹Pirogov Russian National Research Medical University, Moscow

²Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology, Moscow

³Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk

⁴V.M. Bekhterev National Medical Research Center for Psychiatry and Neurology, St. Petersburg

⁵Kusrk State Medical University, Kursk

Aim: to search for indicators of premature aging, as well as to develop treatment tactics for patient management with premature skin aging.

Patients and Methods: the study included 78 patients aged 35 to 45 years without a cosmetic history, who underwent physical, instrumental and laboratory studies, as well as studies with an assessment of age-related skin changes and biological age. The index of involution-induced changes was calculated with identified indicators of premature skin aging. A blind comparative randomized placebo-controlled study was also conducted on the efficacy of the following biorevitalization agents: native hyaluronic acid (HA) 1.8%, a complex preparation with HA, amino acids, vitamins, antioxidants and minerals, collagen.

Results: the threshold level of the total index concerning age-related skin changes in patients aged 35–45 years was calculated: 21 points and below — normal skin aging; 22 points and above — premature skin aging. 18 indicators of premature aging were also identified. It was found that patients with premature aging have an increased risk of adverse events during aesthetic procedures. The efficacy of collagen-based drugs and a complex preparation with HA was statistically significantly higher than the efficacy of native HA or placebo according to ultrasound and clinical evaluation, while the overall patient satisfaction level after a course of intradermal collagen administration was higher.

Conclusion: the index of involution-induced changes >22 was an indicator of premature aging in women 35–45 years old without a cosmetic history. For other patients, it was possible to use indicators to identify patients at high risk of premature aging. The developed index of involution-induced changes, predictors of premature aging and the patient management algorithm can be used in clinical practice for the patients with involution-induced skin changes. For patients with normal aging, the action of native HA is sufficient, while for patients with premature aging / at high risk of premature aging, it is necessary to use a collagen preparation or the complex preparation with HA.

Keywords: skin aging, premature aging, predictors of aging, hyaluronic acid, collagen, intradermal injection, biorevitalization agent.

For citation: Potekaev N.N., Borzykh O.B., Karpova E.I. et al. Patients with premature skin aging. Patient management and risk forecasting. RMJ. 2023;2:52–57.