Skin biopsy during clinical and morphological verification of inflammatory dermatosis

Skin biopsy during clinical and morphological verification of inflammatory dermatosis

M.M. Tlish, A.V. Sycheva, N.L. Sycheva, P.S. Osmolovskaya

Kuban State Medical University, Krasnodar

Background: the main task of skin histology is to establish a diagnosis with the determination of the disease stage and its activity. The process of establishing a clinical and morphological diagnosis of inflammatory dermatosis is fundamentally different from the verification of various skin neoplasms since inflammatory diseases have a nonspecific histological picture.

Aim: to evaluate the diagnostic significance of histological changes in the verification of inflammatory dermatosis based on the data of skin biopsy.

Patients and Methods: a retrospective analysis of 1216 skin biopsy specimens performed by patients with dermatological pathology was conducted. A punch biopsy was used to collect pathological material. To determine the diagnostic significance of histological changes, the clinical data of each patient was compared with the results of their histopathology.

Results: the main variants of the diagnostic significance concerning histological changes were identified when considering clinical and pathological parallel patterns: high diagnostic significance of the histological picture, when a very similar clinical picture is observed; moderate diagnostic significance of the histological picture, when it confirms the clinical diagnosis, but is not decisive; low diagnostic significance with a similar histological picture, when a differential diagnosis is made based on the clinical picture.

Conclusion: the selected variants of the diagnostic significance of histological changes when considering clinical and pathological parallel patterns showed that not in all cases histology data were crucial in the verification of inflammatory dermatosis.

Keywords: biopsy, histology, inflammatory dermatosis, differential diagnosis, diagnosis verification, biopsy specimen.

For citation: Tlish M.M., Sycheva A.V., Sycheva N.L., Osmolovskaya P.S. Skin biopsy during clinical and morphological verification of inflammatory dermatosis. RMJ. 2023;2:58–61.