The role of immunotherapy in the complex treatment of women with chronic cystitis

A.V. Kuzmenko, V.V. Kuzmenko,  T.A. Gyaurgiev

Voronezh State Medical University n.a. N.N. Burdenko of the Ministry of Health of Russia, Voronezh

Cystitis is an infectious and inflammatory process in the bladder wall, localized mainly in the mucous membrane. Every year, more than 7 million visits to the doctor are registered for this disease. In 10% of cases, there are more than two exacerbations within 6 months or three exacerbations per year, which indicates the transition of the acute form into a chronic relapsing one. The mucous membrane lining the lower urinary tract (urothelium) is one of the most important factors providing protection against infection.  At the same time, it also has bacteriostatic properties, anti-adhesive effect, produces secretory IgA and bacterial growth inhibitors. A specific feature of the chronic inflammatory process is the inability to complete acute inflammation by regeneration, which is associated with a violation of intracranial metabolism. Frequent changes in the phases of exacerbation and subsiding of the inflammatory process lead to scarring and sclerosis of a significant part of the bladder mucosa, and as a result, violation of its protective functions. Disorders in the immune system play a significant role in the pathogenesis of many diseases. In this regard, in recent years, much attention has been paid to the use of cytokines as medicines. In essence, cytokines are universal mediators of intercellular interactions, i.e. those molecules with which cells of the immune and other body systems "communicate" with each other. The biological role of these regulatory peptides is indisputable in the development of a wide range of pathophysiological processes: processes of tissue damage and inflammation, as well as repair and regeneration. The inclusion of the drug Superlymph^® containing cytokines and antimicrobial peptides in the complex therapy of chronic cystitis can contribute to improving the effectiveness of treatment, improving the regeneration of the bladder wall, increasing the duration of remission between exacerbations and improving the quality of life of patients.

Keywords: lower urinary tract infections, chronic cystitis, dysuria, cytokines, Superlymph