Urinary tract infection therapy with uric acid nephrolithiasis

Gamidov S.I., Shatylko T.V., Gasanov N.G.

Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology, Moscow

Urinary stone disease (USD) and urinary tract infections are the most common diseases in general urological practice. Typical examples of infected urinary stones are struvite stones with a prothetic infection. However, urolithiasis can also be combined with other pathogens and, thus, has a different chemical composition. Microbes may persist on the surface and inside urate concrements, which is not always reflected in the indicators of general and bacteriological culture of urine, causing a number of unforeseen difficulties in conservative therapy and surgical treatment of urolithiasis. The article describes the role of citrate therapy in infected nephrolithiasis, as well as the possibility of using fosfomycin trometamol in infections associated with urolithiasis and in the framework of antibiotic prophylaxis before endourological interventions. Preoperative and perioperative antibiotic therapy is mandatory for patients with signs of urinary tract infection, as it helps prevent the development of septic complications associated with surgical intervention.

Keywords: urinary tract infections, urinary stone disease, struvite stones, urate nephrolithiasis, citrate therapy, fosfomycin, Fosfomycin Esparma, Blemaren.
For citation: Gamidov S.I., Shatylko T.V., Gasanov N.G. Urinary tract infection therapy with uric acid nephrolithiasis. RMJ. 2019;2:48–52.