Urinary tract infections: current management strategy

A.V. Zaytsev, A.A. Shiryaev, Yu.A. Kim, N.A. Sazonova, E.A. Prilepskaya, A.O. Vasil’ev, D.Yu. Pushkar’

Evdokimov Moscow State University of Medicine and Dentistry

Urinary tract infections (UTIs) are among the most common disorders. High recurrence rate and antimicrobial resistance in urinary tract pathogens significantly increase economic burden of these infections. UTIs are an important cause of morbidity in children, elderly men, and women of all ages. Frequent recurrences, pyelonephritis, kidney disorders in children, and preterm birth are the most common complications. Increasing number of mutations in bacterial genome results in the generation of more aggressive strains. Considering the selection of resistant strains, rational use of antimicrobial drugs and searching for alternative therapy are of primary importance. The rate of the synthesis of novel antibacterial and antimicrobial agents is much less than the rate of the development of antimicrobial resistance. Adequate and rational drug prescription is a challenge in current clinical practice. Physician s should follow basic principles and recommendations on UTI diagnosis and treatment algorithms. These measures will significantly reduce the growth of antimicrobial resistance in urinary tract pathogens.

Keywords: urinary tract infections, antimicrobial resistance, treatment, rational pharmacotherapy.

For citation: Zaytsev A.V., Shiryaev A.A., Kim Yu.A. et al. Urinary tract infections: current management strategy. RMJ. 2019;11:21–26.