Diagnosis and treatment of patients with infertility that developed in the setting of chronic prostatitis

A.A. Shevyrin

Ivanovo State Medical Academy, Ivanovo

Background: male infertility is a clinical manifestation of many different pathological conditions. It is known that physical and chemical changes in the prostate gland that occur during inflammation lead to changes in the semen quality.

Aim: to evaluate the semen quality, the microbiology of sperm and prostatic secretions in patients with infertility and chronic prostatitis, as well as to compare the efficacy of various treatment regimens for this pathology.

Patients and Methods: the study included 50 men of fertility age from 18 to 36 years, suffering from infertility and having various manifestations of pathospermia that occurred in the setting of chronic prostatitis. In group I (n=25), patients received Actifert-Andro dietary supplement in addition to standard treatment for chronic prostatitis according to the standard regimen, in group II (n=25) — only standard drug therapy. The examination was perfor med using general, clinical, laboratory and ultrasound methods in accordance with generally accepted standards.

Results: after three months of treatment in group I, general indices of the semen condition (viscosity, colliquation time, color, admixtures), as well as its morphology and viability were normal almost in all patients. In 6 cases, there was unexpressed sperm agglutination and mild asthenozoospermia, there was no aggregation and MAR-test was negative. In group II, the presence of mucus in the ejaculate, a change in ejaculate pH, an increase in the semen viscosity and in its colliquation time were determined after the therapy course. Adding that, asthenozoospermia was more significant, in some cases — oligo-asthenoteratozoospermia, there were also cases of agglutination and semen aggregation, the MAR-test was weakly positive.

Conclusion: Actifert-Andro addition to the complex therapy of male infertility, developed in the setting of chronic prostatitis, can influe nce different spermatogenesis disorder links, which is especially important given polygenic nature of this disease.

Keywords: male infertility, chronic prostatitis, pathospermia, complex therapy, semen analysis, prostatic fluid.

For citation: Shevyrin A.A. Diagnosis and treatment of patients with infertility that developed in the setting of chronic prostatitis. RMJ. 2020;13:6–9.