Gender and age-related characteristics of vitamin D (25(ОН)D) in Russia

T.M. Zheltikova¹, D.G. Denisov², M.A. Mokronosova¹

¹Scientific Research Institute of Vaccines and Serums named after I.I. Mechnikov, Moscow

²OOO “NPF HELIX” (Research and Production Company HELIX), Saint Petersburg

Aim: to assess gender and age-related characteristics of vitamin D among the population of the Russian Federation.

Patients and Methods: the study was conducted from September 2014 to June 2018. 104321 (one hundred four thousand three hundred twenty one) serums of patients from 105 cities of the Russian Federation were analyzed. Of them female: 80738, which was 77.4% and male — 23583 (22.6%). An electrochemiluminescence was conducted to determine the calcidiol 25(ОН)D concentration in serum. The analysis was carried out on an automatic analyzer Cobas 6000 (Switzerland).

Results: calcidiol concentration was significantly higher than normal and reached 60.45±2.1 ng/ml only in the infant group under 12 months. In children over 1 year of age, 25(ОН)D values in serum significantly decreased, but remained within the normal range, and averaged 40.79±0.79 ng/ml. In all other age groups, the calcidiol concentration was below the specified norm. The patients with calcidiol concentration of less than 30 ng/ml among children under 1 year — 13.9% — were most rarely detected. At the age of 1 to 3 years, the detection rate of patients with 25(ОН)D deficiency in the blood increased by 2.5 times and reached 34.6%. Among patients aged 8 to 14 years and 15 to 20 years, 25(ОН)D deficiency was reported in 76.0% and 79.9%, respectively.Calcidiol average concentration in the female and male serum statistically significantly differed only in the critical age group from 18 to 35 years and in women, it was higher, althoughit did not exceed 27.15±0.35 ng/ml.

Conclusion: the study results indicate that both the concentration and the detection rate of 25(ОН)D deficiency of in serum depended on the patient age and in some age groups — on gender.

Keywords: vitamin D, calcidiol (25(OH)D), gender and age-related characteristics of vitamin D.

For citation: Zheltikova T.M., Denisov D.G., Mokronosova M.A. Gender and age-related characteristics of vitamin D (25(ОН)D) in Russia.
RMJ. 2019;12:51–56.