Ulcerative lesion of the intestine in the onset of Behçet’s disease: a clinical case report

Ulcerative lesion of the intestine in the onset of Behçet’s disease: a clinical case report

A.A. Klimenko^1,2, T.K. Loginova^1, E.P. Mikheeva², M.R. Mazra¹, A.I. Fedotova¹, M.A. Karanadze¹

¹Pirogov Russian National Research Medical University, Moscow

²N.I. Pirogov City Clinical Hospital No. 1, Moscow 

Behçet’s disease (BD) is a rare multisystem autoinflammatory disorder characterized by vasculitis affecting vessels of various calibers and diverse clinical manifestations. This article presents a clinical case report of a 51-year-old patient, whose disease onset was with an ulcerative intestinal lesion requiring resection of the large intestine. Subsequently, the patient developed recurrent mucosal ulcers, arthritis, skin boil-like rashes, and elevated laboratory markers of inflammation. The HLA-B51 test was positive. Improvement was achieved following treatment with sulfasalazine and colchicine. This case demonstrates diagnostic difficulties during the disease onset with predominant gastrointestinal tract involvement, which can lead to a delay in diagnosis and initiation of adequate treatment. In such situations, a thorough history taking, clinical and laboratory assessment, and exclusion of inflammatory bowel diseases are necessary for the timely verification of Behçet’s disease.

Keywords: Behçet’s disease, systemic vasculitis, aphthous stomatitis, gastrointestinal tract involvement, pathergy test, genetically engineered biological products.

For citation: Klimenko A.A., Loginova T.K., Mikheeva E.P., Mazra M.R., Fedotova A.I., Karanadze M.A. Ulcerative lesion of the intestine in the onset of Behçet’s disease: a clinical case report. RMJ. 2025;7:47–51. DOI: 10.32364/2225-2282-2025-7-9