Comparative analysis of compositions of dietary supplements containing collagen

Comparative analysis of compositions of dietary supplements containing collagen

O.А. Shavlovskaya

Olga A. Shavlovskaya, e-mail: shavlovskaya@1msmu.ru

International University of Restorative Medicine, Moscow

Today, products containing collagen have become a trend in the consumption of patients with joint and spinal diseases. Different types of collagen differ in their source, production technology, and mechanism of action. Undenatured type II collagen (UC-II) is an integral part of the cartilage matrix in joints. In 2025, the collagen molecule was included in the Clinical Guidelines "Polyarthrosis (Generalized Osteoarthritis)» by the Russian Ministry of Health, with a high level of evidence (2B). Oral administration of UC-II leads to: 1) suppression of hyperproduction of proinflammatory cytokines, 2) slowing of cartilage degradation, 3) acceleration of cartilage regeneration. Many dietary supplements (DS) contain collagen (undenatured, hydrolyzed, and peptides). The article provides a comparative analysis of the compositions of dietary supplements containing collagen available on the pharmaceutical market based on the following criteria: dosage form, composition of active ingredients, dosage of collagen, source of collagen, duration of the course, presence of additional active ingredients, presence of auxiliary substances, and assessment of their possible negative impact on the body. Dietary supplements containing collagen details of which are in the public domain, were analyzed.

Keywords: dietary supplements, undenatured type II collagen, Chondroguard TRIO, osteoarthritis, low back pain.

For citation: Shavlovskaya O.А. Comparative analysis of compositions of dietary supplements containing collagen. RMJ. 2026;2:41–46. DOI: 10.32364/2225-2282-2026-2-8