Reconstructive local injection therapy with hyaluronate: case report

Reconstructive local injection therapy with hyaluronate: case report

O.A. Kaplunov^1,2, K.O. Kaplunov^1,2

¹Volgograd State Medical University, Volgograd

²Multidisciplinary Medical Center, Volgograd

The article presents a case study concerning a patient diagnosed with stage II–III knee osteoarthritis (OA), classified according to the Kellgren-Lawrence criteria, who underwent conservative outpatient treatment with injectable medications derived from hyaluronic acid salts. This case is of notable interest to medical practitioners due to its increasing prevalence: the patient has a prior history of total knee arthroplasty on the left side for clinically apparent idiopathic OA. Despite this intervention, the contralateral joint was diagnosed with advanced gonarthrosis, rendering conservative treatment ineffective. Consequently, a reconstructive local injection therapy program was proposed, involving a single application of 2% sodium hyaluronate formulated as a bionic cross-linked hyaluronic acid. Two weeks post-treatment, both subjective and objective improvements were recorded: a reduction in pain intensity on the visual analog scale, positive ultrasound findings indicating decreased severity of synovitis in the articular tissues, and an increased range of motion in the affected joint. Concurrently, there were significant improvements in the laboratory-based inflammation marker, with C-reactive protein levels decreasing from 29 to 14 mg/L.

Keywords: osteoarthritis, gonarthrosis, sodium hyaluronate, bionic cross-link.

For citation: Kaplunov O.A., Kaplunov K.O. Reconstructive local injection therapy with hyaluronate: case report. RMJ. 2024;8:26–30.