Nutritional support for patients with pain syndrome: clinical use of Cartilox nutraceutical

Nutritional support for patients with pain syndrome: clinical use of Cartilox nutraceutical

O.A. Shavlovskaya

International University of Restorative Medicine, Moscow

In adults, over 90% of the collagen matrix in cartilage is composed of type II collagen, which serves as the primary structural component of the cartilage extracellular matrix. The robust structure of collagen is attributed to stable intermolecular hydrogen bonding formed by glycine residues in adjacent polypeptide chains. Clinically, type II collagen is utilized in two forms — non-denatured and hydrolyzed peptides, each varying by degrees of hydrolysis — for the prevention and management of osteoarthritis. The therapeutic efficacy of non-denatured type II collagen extracts is linked to their ability to modulate innate and adaptive immune mechanisms, thereby decreasing the activity of pro-inflammatory cytokines and prostaglandins. Hydrolyzed type II collagen consists of collagen hydrolysate, comprising individual amino acids, dipeptides, and tripeptides. The administration of hydrolyzed collagen enhances anabolic processes within the cartilage extracellular matrix, promoting regeneration and stability of articular cartilage. Its mechanism of action is multifaceted, involving direct stimulation of fibroblasts and M2-like macrophages, as well as mechanisms related to oral tolerance. In the Russian Federation, the dietary supplement Cartilox is employed for preventative measures. Cartilox combines collagen peptides, curcumin, Boswellia serrata extract, hyaluronic acid, and black pepper to support joint health. This article presents case studies of three patients with musculoskeletal system pathologies and high physical activity levels. These individuals were monitored over a year and underwent two courses of Cartilox supplementation, experiencing significant reductions in pain and improved joint mobility as a positive outcome.

Keywords: dietary supplements, type II collagen, hydrolyzed collagen, collagen peptides, osteoarthritis, quality of life, Cartilox.

For citation: Shavlovskaya O.A. Nutritional support for patients with pain syndrome: clinical use of Cartilox nutraceutical. RMJ. 2024;8:31–34.