Localized scleroderma in a newborn (case report)
DOI: 10.32364/2618-8430-2022-5-2-169-172
N.I. Akhmina1, P.S. Utkin2, M.P. Shalatonin3, Zh.L. Chabaidze1, A.A. Dement’ev1, A.L. Zaplatnikov1
1Russian Medical Academy of Continuous Professional Education, Moscow,
Russian Federation
2Children’s Infectious Clinical Hospital No. 6, Moscow, Russian Federation
3Morozov Children’s City Clinical Hospital, Moscow, Russian Federation
Scleroderma is a rare condition in pediatrics although it ranks third (after juvenile idiopathic arthritis and systemic lupus erythematosus) among rheumatic diseases in children. Congenital scleroderma is considered casuistic since only single case reports are available in publications worldwide. The etiology of congenital scleroderma remains elusive. The principal pathogenic mechanisms are vascular network impairment, immune system dysfunction with abnormal regulation of cytokine release and altered collagen synthesis with fibroblast proliferation and fibrosis. This paper describes a newborn girl with congenital localized nodular scleroderma whose clinical presentations were detected at birth. The authors discuss difficulties with the diagnosis based on clinical and routine lab and instrumental tests. The role of modern morphological studies (given the lack of specific lab tests) to diagnose scleroderma in a newborn is emphasized. Finally, this paper provides a brief review of published data on congenital scleroderma.
Keywords: congenital scleroderma, children, diagnostics, differential diagnosis, morphological studies.
For citation: Akhmina N.I., Utkin P.S., Shalatonin M.P. et al. Localized scleroderma in a newborn (case report). Russian Journal of Woman and Child Health. 2022;5(2):169–172 (in Russ.). DOI: 10.32364/2618-8430-2022-5-2-169-172.
About the authors:
Nataliya I. Akhmina — Dr. Sc. (Med.), professor of the Prof. V.V. Gavryushov Department of Neonatology, Russian Medical Academy of Continuous Professional Education; 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0000-0002-5870-4938.
Petr S. Utkin — dermatologist, Children’s Infectious Clinical Hospital No. 6; 2B, 3rd Likhachevskiy lane, Moscow, 125438, Russian Federation; ORCID iD 0000-0001-5934-8480.
Mikhail P. Shalatonin — pathologist, Morozov Children’s City Clinical Hospital; 1/9, 4th Dobryninskiy pass., Moscow, 119049, Russian Federation; ORCID iD 0000-0002-9768-9646.
Zhuzhuna L. Chabaidze — C. Sc. (Med.), associate professor of the Prof. V.V. Gavryushov Department of Neonatology, Russian Medical Academy of Continuous Professional Education; 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0000-0002-2192-796X.
Aleksandr A. Dement’ev — C. Sc. (Med.), associate professor of the Prof. V.V. Gavryushov Department of Neonatology, Russian Medical Academy of Continuous Professional Education; 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0000-0002-7640-1172.
Andrey L. Zaplatnikov — Dr. Sc. (Med.), Professor, Vice-chancellor for Instructional Work, Head of the Prof. N.N. Gavryushov Department of Neonatology, professor of the Acad. G.N. Speranskiy Department of Pediatrics, Russian Medical Academy of Continuous Professional Education; 2/1 Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0000-0003-1303-8318.
Contact information: Andrey L. Zaplatnikov, e-mail: zaplatnikov@mail.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interests.
Received 09.03.2022.
Revised 01.04.2022.
Accepted 26.04.2022.
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