Treat-to-target in spondyloarthritis
Wei J. C.

Chung Shan Medical University, Taiwan

Ankylosing spondylitis (AS) is a chronic inflammatory disease involving spine, peripheral joints and extra-articular manifestations. AS is often combined with psoriasis and inflammatory bowel diseases, forming a group of «seronegative spondyloarthropathies». The treatment goals for spondyloarthritis are maintenance of physical function, control of disease activity and prevention of X ray progression. However, not like the well-established treat-to-target (T2T) guidance in rheumatoid arthritis (RA), the T2T concept for treating AS is still immature. Clinical evidence of T2T in AS is still lacking.
To develop the foundations of the T2T strategy in the AS, several research agendas need to be accomplished: to develop and formulate a generally accepted measureable treatment target, defined through experts’ consensus; develop a clear algorithm for monitoring disease activity and adjusting therapy; well-designed comparative clinical trials to compare this T2T strategy with the current standard of treatment should be conducted to demonstrate long-term benefits 
and risks.

Key words: ankylosing spondylitis, rheumatoid arthritis, psoriasis, remission, activity, treat-to-target.
For citation: Wei J.C. Treat-to-target in spondyloarthritis // RMJ. 2018. № 4(I). P. 3–6.