Comorbidities in psoriatic arthritis

Comorbidities in psoriatic arthritis

D.V. Somov, D.Yu. Andriyashkina, A.A. Kondrashov, A.A. Klimenko, N.A. Shostak 

Pirogov Russian National Research Medical University, Moscow 

Background: psoriatic arthritis (PsA) is a chronic inflammatory disease characterized by arthritis, enthesitis, dactylitis, and spondylitis associated with psoriasis. In addition to joint and skin lesions, more than half of the patients with PsA have at least one comorbidity. Currently, new attempts are being made to study comorbidities in these patients.

Aim: to study the prevalence of various comorbidities and their risk in patients with PsA based on PsA variant and its duration.

Patients and Methods: this single-center retrospective study was conducted from 2017 to 2022 and included 104 patients. PsA diagnosis was established based on the CASPAR criteria (2006). Patients were divided into groups based on the PsA type that were shaped based on clinical guidelines. The diagnosis of comorbidities was established and recorded using ICD-10.

Results: distal PsA was diagnosed in 1 patient (0.9%), arthritis mutilans in 2 patients (1.9%), spondylitis in 32 patients (30.8%), asymmetric PsA in 34 patients (32.7 %), and symmetric PsA in 35 patients (33.7%). Comorbidities were detected in 80 patients (76.9%). The most common comorbidities were cardiovascular, endocrine, and gastrointestinal disorders. A potential association between various PsA types, their duration, and the risk of comorbidities was revealed.

Conclusions: novel potential patterns in the development of comorbidities in patients with PsA were identified. Further studies on this issue will improve the management of patients with various PsA types.

Keywords: psoriatic arthritis, comorbidity, psoriasis, concomitant diseases, arthritis mutilans, psoriatic spondylitis, monoarthritis, oligoarthritis, polyarthritis.

For citation: Somov D.V., Andriyashkina D.Yu., Kondrashov A.A., Klimenko A.A., Shostak N.A. Comorbidities in psoriatic arthritis. RMJ. 2023;10:4–7.