Phenylbutazone: non-selective NSAIDs in modern medical practice

I.S. Svintsitskaya, K.Yu. Volkov, S.G. Bologov

S.M. Kirov Military Medical Academy, St. Petersburg

Despite the long history of the use of non-steroidal anti-inflammatory drugs (NSAIDs) in clinical practice, research continues concerning the comparative evaluation of the efficacy and safety of various NSAIDs classes, taking into account their selectivity with respect to the effect on cyclooxygenase. The article is devoted to one of the most well-known and studied drugs — phenylbutazone. The review reflects some historical aspects of phenylbutazone use, it’s pharmacokinetic and pharmacodynamic patterns that cause a prolonged effect. The review also indicates the main adverse events and methods of their control. The expediency of using parenteral forms of NSAIDs (in particular phenylbutazone) in patients with acute pain, providing rapid onset of analgesic effect, is substantiated. It is noted that a balanced approach to phenylbutazone use can minimize the risk of severe toxic responses (primarily from the b one marrow), significantly limiting the drug use by specialists, including in outpatient practice. The article presents the study results confirming the efficacy and safety of phenylbutazone use in injectable form for the relief of acute pain syndrome associated with degenerative-dystrophic and rheumatic diseases of the musculoskeletal system.

Keywords: phenylbutazone, non-steroidal anti-inflammatory drugs, efficacy, safety, acute pain.

For citation: Svintsitskaya I.S., Volkov K.Yu., Bologov S.G. Phenylbutazone: non-selective NSAIDs in modern medical practice. RMJ. 2021;7:62–65.