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Challenges in the diagnosis of Hodgkin lymphoma in a child with asthma

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Abstract

DOI: 10.32364/2587-6821-2024-8-3-9

N.A. Belykh¹, A.P. Chernenko¹, Yu.V. Mikhaylova², I.V. Piznyur¹

¹Ryazan State Medical University, Ryazan, Russian Federation

²St. Vladimir Children's City Clinical Hospital, Moscow, Russian Federation

Hodgkin's lymphoma (HL) is a B-cell malignant lymphoproliferative disease. It is characterized by the presence of giant Reed-Berezovsky-Sternberg cells, which can be detected by microscopy of affected lymph nodes. The incidence of HL in the Russian Federation is 2.2 per 100,000 per year, and it ranks 26th among other malignancies worldwide. The disease has two peaks, occurring at the ages of 15–19 years and after 50 years. Men are slightly more commonly affected than women. Young patients with HL are predominantly women, while older patients are predominantly men. The etiology of HL remains unclear. Clinically, the disease is characterized by asymptomatic lymph node enlargement, intoxication, intermittent fever, and, in patients with massive mediastinal involvement, chest pain, cough, dyspnea, and symptoms of superior vena cava syndrome. The article discusses the prevalence, specifics of treatment, and association with allergic diseases, and describes a 13-year-old child with nodular sclerosis classic Hodgkin's lymphoma.

Keywords: Hodgkin's lymphoma, nodular sclerosis, allergic disease, asthma, lymphoproliferative disease, differential diagnosis.

For citation: Belykh N.A., Chernenko A.P., Mikhaylova Yu.V., Piznyur I.V. Challenges in the diagnosis of Hodgkin lymphoma in a child with asthma. Russian Medical Inquiry. 2024;8(3):176–182 (in Russ.). DOI: 10.32364/2587-6821-2024-8-3-.9

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