Clinical Ophthalmology.
People Policies Reception of articles Other

Modern approaches to acute bronchitis pharmacotherapy. Benefits of herbal medicine

Abstract


A.V. Shchulkin

Ryazan State Medical University

Bronchitis is an inflammatory pulmonary disease without the infiltrative changes formation in the parenchyma. The incidence of acute bronchitis in Russia rates on average 75–250 per 1000 children annually, i.e. by 2 orders of magnitude higher than the pneumonia incidence. According to the clinical recommendations of the Ministry of Health of the Russian Federation on the acute bronchitis treatment in children, it is not recommended to prescribe antibiotics, antihistamines, and electrical procedures and use mustard plaster and burn bandage. Mucolytic and expectorant means are recommended in the presence of dense sputum. The herbal medicine role in the treatment of cough is difficult to overestimate. Drugs, including extracts of thyme grass, ivy leaves, and primrose roots, are effective for the cough treatment. Thyme herb has a secretolytic, expectorant, bronchospasmolytic, antibacterial and anti-inflammatory properties, whereas i vy leaves and primrose root have an expectorant and antispasmodic effect on the respiratory tract. One of the most studied and effective herbal remedies for the acute bronchitis treatment is the Bronchipret® syrup (thyme herb and ivy leaves extracts combination) and Bronchipret® TP (thyme herb and primrose root extracts combination). Bronchipret® and Bronchipret® TP efficacy and safety in the acute bronchitis pharmacotherapy has been proven in numerous clinical studies, the most significant of which are discussed in this review.

Keywords: bronchitis, tracheobronchitis, cough, herbal medicine, thyme herb, primrose root, ivy leaves, children, Bronchipret.

For citation: Shchulkin A.V. Modern approaches to acute bronchitis pharmacotherapy. Benefits of herbal medicine. RMJ. Medical Review. 2019;5:30–34.

References
1. Острый бронхит у детей. Клинические рекомендации Союза педиатров России. (Электронный ресурс). URL: http://pediatr-russia.ru/sites/default/files/file/kr_obr.pdf (дата обращения: 17.05.2019). [Acute bronchitis in children. Clinical recommendations of the Union of Pediatricians of Russia. (Electronic resource). URL: http://pediatr-russia.ru/sites/default/files/file/kr_obr.pdf (access date17.05.2019) (in Russ.)].
2. Gonzales R., Sande M.A. Uncomplicated acute bronchitis. Ann Intern Med. 2000;133:981–991.
3. Macfarlane J.R., Colville A., Guion A. et al. Prospective study of aetiology and outcome of adult lower-respiratory tract infections in the community. Lancet. 1993;341:511–514.
4. Macfarlane J., Holmes W., Gard P. et al. Prospective study of the incidence, aetiology and outcome of adult lower respiratory tract illness in the community. Thorax. 2001;56:109–114.
5. Smith S.M., Fahey T., Smucny J., Becker L.A. Antibiotics for acute bronchitis. Cochrane Database of Systematic Reviews 2017, Issue 6. CD000245. DOI: 10.1002/14651858.CD000245.pub4.
6. ESCOP Monograph, Thymi herba (Thyme). European Scientific Cooperation on Phytomedicine, Elburg (2003).
7. ESCOP Monograph, Hedera helices folium (Ivy Leaf). European Scientific Cooperation on Phytomedicine, Elburg (2003).
8. ESCOP Monograph, Primulae radix (Primrose root). European Scientific Cooperation on Phytomedicine, Elburg (2003).
9. Кеммерих Б., Эберхардт Р., Штаммер Х. Эффективность и переносимость комбинации травы тимьяна и плюща в виде жидкого экстракта против плацебо у пациентов, страдающих острым бронхитом с продуктивным кашлем. Проспективное двойное слепое плацебо-контролируемое клиническое исследование. РМЖ. 2008;16(20):3–10. [Kemmerich B., Eberhardt R., Stammer H. Efficacy and tolerability of a combination of thyme herb and ivy in the form of a liquid extract against placebo in patients suffering from acute bronchitis with productive cough. A prospective, double-blind, placebo-controlled clinical trial. RMJ. 2008;16(20):3–10 (in Russ.)].
10. Кеммерих Б. Оценка эффективности и переносимости готовой комбинации сухих экстрактов травы тимьяна и корня первоцвета у взрослых, страдающих острым бронхитом с продуктивным кашлем. Проспективное двойное слепое плацебо-контролируемое многоцентровое клиническое исследование. РМЖ. 2009;17(16):1–9. [Kemmerich B. Evaluation of the effectiveness and tolerability of the finished combination of dry extracts of thyme herb and primrose root in adults suffering from acute bronchitis with productive cough. A prospective, double-blind, placebo-controlled multicenter clinical study. RMJ. 2009;17(16):1–9 (in Russ.)].
11. Ernst E., Maerz R., Sieder C. A controlled multi-centre study of herbal versus synthetic secretolytic drugs for acute bronchitis. Phytomedicine: international journal of phytotherapy and phytopharmacology. 1997;4(4):287–293. DOI:10.1016/S0944–7113 (97) 80035–9.
12. Руженцова Т.А., Будаковская А.В., Горелов А.В. Фитотерапия в лечении острых респираторных инфекций у детей. РМЖ. 2014;6:1–3. [Ruzhentsova T.A., Budakovskaya A.V., Gorelov A.V. Herbal medicine in the treatment of acute respiratory infections in children. RMJ. 2014;6:1–3 (in Russ.)].
13. Дрынов Г.И. Опыт профилактики и терапии респираторно-вирусных инфекций у больных с аллергическими заболеваниями. РМЖ. 2011;23:3–5. [Drinov G.I. Experience in the prevention and treatment of respiratory viral infections in patients with allergic diseases. RMJ. 2011;23:3–5 (in Russ.)].
14. Марциан О. Лечение острого бронхита у детей и подростков. Постмаркетинговое наблюдательное исследование подтвердило эффективность и безопасность комбинации жидкого экстракта травы тимьяна и листьев плюща. РМЖ. 2010;18(21):3–6. [Martian O. Treatment of acute bronchitis in children and adolescents. A post-marketing observational study confirmed the efficacy and safety of a combination of liquid thyme herb extract and ivy leaves. RMJ. 2010;18(21):3–6 (in Russ.)].
15. Christ-Crain M., Jaccard-Stolz D., Bingisser R. et al. Effect of procalcitonin-guided treatment on antibiotic use and outcome in lower respiratory tract infections: cluster-randomised, single- blinded intervention trial. Lancet. 2004; 363 (9409):600–7.
16. Намазова-Баранова Л.С., Котлярова М.С., Ровенская Ю.В. и др. Сравнение эффективности и безопасности фито- и антибиотикотерапии при лечении острого бронхита у детей: результаты многоцентрового двойного слепого рандомизированного клинического исследования. Педиатрическая фармакология. 2014;11(5):22–29. [Namazova-Baranova L.S., Kotlyarova M.S., Rovenskaya Yu.V. et al. Comparison of the efficacy and safety of phyto- and antibiotic therapy in the treatment of acute bronchitis in children: results of a multicenter double-blind randomized clinical trial. Pediatric Pharmacology. 2014; 11 (5):22–29 (in Russ.)].
17. Нисевич Л.Л., Намазова Л.С., Волков К.С. и др. Всегда ли необходимы антибиотики для лечения затяжного кашля у детей? Педиатрическая фармакология. 2008;5(3):2–8. [Nisevich L.L., Namazova L.S., Volkov K.S. etc. Are antibiotics always necessary for the treatment of prolonged cough in children? Pediatric Pharmacology. 2008;5(3):2–8].
18. Сафина А.И. Лечение кашля при острых респираторных инфекциях у часто болеющих детей. Вопросы современной педиатрии. 2014;13(1):180–183. [Safina A.I. Treatment of cough in case of acute respiratory infections in frequently ill children. Current pediatrics. 2014;13(1):180–183 (in Russ.)].

License Creative Commons
This work is licensed under a Creative Commons «Attribution» 4.0 License.
Read the article in PDF in Russian


Previous article
Next article
Combined acute enteric infections in chi...
0
11266
Salvage surgery in residual ovarian germ...
0
3683
All articles

Распечатать