Advanced approaches to diagnosis and therapy of lipoid pneumonia in children
DOI: 10.32364/2618-8430-2025-8-4-15
A.B. Malakhov1,2,3, N.A. Geppe1, M.D. Shakhnazarova1, P.V. Berezhanskyi1,2,3, T.A. Gutyrchik1,2, A.Yu. Sedova1, Sh.A. Gitinov2, A.N. Nikolishin2, V.V. Gorev2,4, A.V. Shishova5, M.G. Dalgatov1
1I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow,
Russian Federation
2Morozov Children's City Clinical Hospital, Moscow, Russian Federation
3Moscow Region Childhood Scientific Research Clinical Institute, Moscow, Russian Federation
4Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
5Ivanovo State Medical Academy, Ivanovo, Russian Federation
Lipoid pneumonia is a rare form of interstitial pneumonia associated with uptake of lipid-containing substances in the alveoli due to their aspiration or accumulation of endogenous lipids in the lung tissue. The paper presents literature data and the authors' own clinical case report of lipoid pneumonia in a 2.6-year-old child with severe epilepsy, infantile cerebral palsy, and dysphagia. The disease was associated with prolonged use of petroleum jelly oil as a laxative. Risk factors, clinical features, as well as advanced approaches to diagnosis and backbone therapy are highlighted. Combined use of inhaled corticosteroids, low-dose macrolides, and intrapulmonary percussion ventilation is reported to have a positive effect.
Keywords: lipoid pneumonia, lipid-containing agents, iGCS, CT, intrapulmonary percussion ventilation, macrolides.
For citation: Malakhov A.B., Geppe N.A., Shakhnazarova M.D., Berezhanskyi P.V., Gutyrchik T.A., Sedova A.Yu., Gitinov Sh.A., Nikolishin A.N., Gorev V.V., Shishova A.V., Dalgatov M.G. Advanced approaches to diagnosis and therapy of lipoid pneumonia in children. Russian Journal of Woman and Child Health. 2025;8(4):383–391 (in Russ.). DOI: 10.32364/2618-8430-2025-8-4-15
ABOUT THE AUTHORS:
Alexander B. Malakhov — Dr. Sc. (Med.), Professor of the Department of Children's Diseases, N.F. Filatov Clinical Institute of Children's Health, I.M. Sechenov First Moscow State Medical University (Sechenov University); 8 Build. 2, Trubetskaya str., Moscow, 119991, Russian Federation; Chief Consultant Children Pulmonologist, pulmonologist, Morozov Children's City Clinical Hospital; 1/9, 4th Dobryninskiy pass., Moscow, 119049, Russian Federation; Head of the Department of Pediatrics, Research Clinical Institute of Childhood of the Moscow Region; 62, Bolshaya Serpukhovskaya str., Moscow, 115093, Russian Federation; ORCID iD 0000-0002-2686-8284
Natalia A. Geppe — Dr. Sc. (Med.), Professor, Honored Doctor of the Russian Federation, Head of the Department of Children's Diseases, N.F. Filatov Clinical Institute of Children's Health, I.M. Sechenov First Moscow State Medical University (Sechenov University); 8 Build. 2, Trubetskaya str., Moscow, 119991, Russian Federation; ORCID iD 0000-0003-0547-3686
Marina D. Shakhnazarova — C. Sc. (Med.), Assistant Professor at the Department of Pediatric Diseases, N.F. Filatov Clinical Institute of Pediatric Health, I.M. Sechenov First Moscow State Medical University (Sechenov University); 8 Build. 2, Trubetskaya str., Moscow, 119991, Russian Federation; ORCID iD 0000-0003-3512-5455
Pavel V. Berezhansky — Dr. Sc. (Med.), Professor of the Department of Children's Diseases, N.F. Filatov Clinical Institute of Children's Health, I.M. Sechenov First Moscow State Medical University (Sechenov University); 8 Build. 2, Trubetskaya str., Moscow, 119991, Russian Federation; pediatrician, pulmonology department, Morozov Children's City Clinical Hospital; 1/9, 4th Dobryninskiy pass., Moscow, 119049, Russian Federation; Senior Researcher of the Department of Pediatrics, Research Clinical Institute of Childhood of the Moscow Region; 62, Bolshaya
Serpukhovskaya str., Moscow, 115093, Russian Federation; ORCID iD 0000-0001-5235-5303
Tatiana A. Gutyrchik — C. Sc. (Med.), Pediatrician, Pulmonologist, Morozov Children's City Clinical Hospital; 1/9, 4th Dobryninskiy pass., Moscow, 119049, Russian Federation; ORCID iD 0000-0002-8421-1694
Alyona Yu. Sedova — C. Sc. (Med.), Pulmonologist, Teaching Assistant at the Department of Pediatric Diseases, N.F. Filatov Clinical Institute of Pediatric Health, I.M. Sechenov First Moscow State Medical University (Sechenov University); 8 Build. 2, Trubetskaya str., Moscow, 119991, Russian Federation.
Shamil A. Gitinov — Pediatrician, Pulmonological Department of Morozov Children's City Clinical Hospital; 1/9, 4th Dobryninskiy pass., Moscow, 119049, Russian Federation; ORCID iD 0000-0001-6975-1337
Alexander N. Nikolishin — Deputy Chief Physician for Anesthesiology and Intensive Care at Morozov Children's City Clinical Hospital; 1/9, 4th Dobryninskiy pass., Moscow, 119049, Russian Federation; ORCID iD 0000-0001-7226-0707
Valeryi V. Gorev — C. Sc. (Med.), Chief Physician of Morozov Children's City Clinical Hospital; 1/9, 4th Dobryninskiy pass., Moscow, 119049, Russian Federation; Russian Medical Academy of Continuous Professional Education; 2/1, Build. 1, Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0000-0001-8272-3648
Anastasia V. Shishova — Dr. Sc. (Med.), Assistant Professor, Professor of the Department of Polyclinic Pediatrics, Dean of the Faculty of Pediatrics, Ivanovo State Medical Academy; 8, Sheremetevskiy pass., Ivanovo, 153012, Russian Federation; ORCID iD 0000-0003-0471-0790
Mikail' G. Dalgatov — Student, N.V. Sklifosovskiy Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University); 8 Build. 2, Trubetskaya str., Moscow, 119991, Russian Federation; ORCID iD 0009-0002-1342-3590
Contact information: Marina D. Shakhnazarova, e-mail: marinashakh@mail.ru
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 02.10.2025.
Revised 27.10.2025.
Accepted 21.11.2025.
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