Metabolic activities of microbiota and metabiotics
Kornienko E.A. 

Saint Petersburg State Pediatric Medical University

Intestinal microbiota has important functions, including a metabolic one. Microbiota is actively involved in almost all types of metabolism, digesting various
food ingredients: proteins, fats and carbohydrates, synthesizing vitamins. Important products of bacterial digestion of carbohydrates are short chain fatty
acids (SCFA): acetic, propionic and butyric. Positive effects of SCFA include promotion of bifidobacteria growth, pathogens inhibition, reduction of the level of toxic and carcinogenic metabolites improvement of Na⁺, K⁺, Ca⁺⁺, Mg⁺⁺, Zn⁺⁺ absorption; normalization of GIT motility, body energy supply, enhancement
of liver glycogenesis, reduction of ketone formation and anti-inflammatory action.
Changes in the spectrum of microbial metabolites is one of the causes of intestinal diseases, including colon cancer. Since the end products of microbial metabolism depend both on food character and microbiota composition, intake of ready microbial metabolites—metabiotics—has a more predictable effect.
These drugs, in particular, Hylak forte, are effective in the treatment of a variety of intestinal diseases.

Key words: metabiotics, intestinal microbiota, short chain fatty acids, Hylak forte

For citation: Kornienko E.A. Metabolic activities of microbiota and metabiotics // RMJ. 2016. № 18. P. 1196–1201.