The use of irrigation therapy with hypertensive solutions for the treatment of infectious rhinosinusitis in children
Garashchenko T.I.^1,2, Tarasova G.D.¹, Tulina A.S.¹, Ilenko L.I.², Garashchenko M.V.², Lazareva S.I.<sup>2

1</sup> Federal Scientific-Clinical Center of Otorhinolaryngology of the Federal Medico-Biological Agency of the Russian Federation, Moscow
² Pirogov Russian National Research Medical University, Moscow

Aim: to study the efficacy and safety of the Aqualor Forte nasal spray (hypertonic sea water solution) in children with acute infectious rhinosinusitis (AIRS).
Patients and Methods: 100 children aged from 6 to 14 years with AIRS participated in the study. Patients were divided into 2 groups: group 1 - 50 patients received Aqualor Forte 3 times a day, group 2 - 50 children received a drug containing 0.1% xylometazoline solution 2-3 times a day. Patient examination was performed before the first application of the drugs and in 15 minutes after the application, then after 1 hour, 72 ± 6 hours, 7 days. The dynamics of the course of the disease was assessed in scores, taking into account the subjective and objective symptoms of AIRS.
Results: a more pronounced decrease in subjective and objective symptoms of AIRS was detected during the monotherapy with Aqualor Forte, as compared to the use of xylometazoline drug. According to the data of anterior active rhinomanometry (AARM), the decongestive effect of xylometazoline was higher than that of Aqualor Forte in 15 minutes after the first application, it was comparable after 1 hour, but after 3 and 7 days the decongestive effect of Aqualor Forte was significantly higher. After 3 to 7 days of the use of xylometazoline there is a decrease of the total volumetric air flow and an increase of the AARM total resistance, which indicates a growing disorder in the microcirculation system of the mucous tunic of nose. No such disorders were detected in the group of patients who used Aqualor Forte. The use of xylometazoline caused the undesirable effects in 20 (40%) patients. There were no undesirable effects in the group of patients treated with Aqualor Forte.
Conclusion: Aqualor Forte, containing the hypertonic natural sterile sea water, can be recommended as a monotherapy in children with AIRS for a safe relief of nasal breathing.

Key words: acute infectious rhinosinusitis, hypertonic sea water solution, anterior active rhinomanometry, treatment of rhinosinusitis in children, Aqualor Forte.
For citation: Garashchenko T.I., Tarasova G.D., Tulina A.S. et al. The use of irrigation therapy with hypertensive solutions for the treatment of infectious rhinosinusitis in children // RMJ. 2018. № 2(II). P. 79–84.