Severe COVID-19 course outcome in a child with morbid obesity
DOI: 10.32364/2618-8430-2024-7-1-12
D.A. Kartashova1, T.A. Bokova1,2, I.V. Razheva1, A.S. Bevz1, S.V. Vorontsova1
1M.F. Vladimirskiy Moscow Regional Research and Clinical Institute, Moscow, Russian Federation
2Pirogov Russian National Research Medical University, Moscow, Russian Federation
Obesity is one of the most essential medical and social problems. When it was noted that obese children had higher risks of disease, complications and mortality, the overweight effect on the course and outcome of infectious respiratory diseases became particularly important during the flu pandemic. According to numerous studies, obesity has been considered as a predictor of the adverse and even fatal outcome of COVID-19, participating in the formation of multisystem inflammatory syndrome in children (MIS-C). This article demonstrates a case study of severe COVID-19 complicated by MIS-C, multiple thrombosis, and multiple organ dysfunction syndrome in a 9-year-old child with morbid obesity. The article describes the patient management and the complex of diagnostic and therapeutic measures conducted. The main pathogenetic mechanisms of the inflammatory process explaining the association between obesity and the SARS-CoV-2 coronavirus damaging effects are also considered. The need for timely diagnosis and treatment of both obesity itself and comorbid pathology is shown to prevent potentially life-threatening conditions.
Keywords: children, obesity, new coronavirus infection, COVID-19, SARS-CoV-2, multisystem inflammatory syndrome, premorbid history, thrombosis, multiple organ dysfunction syndrome.
For citation: Kartashova D.A., Bokova T.A., Razheva I.V., Bevz A.S., Vorontsova S.V. Severe COVID-19 course outcome in a child with morbid obesity. Russian Journal of Woman and Child Health. 2024;7(1):79–85 (in Russ.). DOI: 10.32364/2618-8430-2024-7-1-12.
About the authors:
Darya A. Kartashova — junior researcher at the Department of Pediatrics, M.F. Vladimirskiy Moscow Regional Research and Clinical Institute; 61/2, Shchepkin str., Moscow, 129110, Russian Federation; ORCID iD 0000-0002-0005-7352.
Tatyana A. Bokova — Dr. Sc. (Med.), Head of the Department of Pediatrics, M.F. Vladimirskiy Moscow Regional Research and Clinical Institute; 61/2, Shchepkin str., Moscow, 129110, Russian Federation; Professor of the Department of Pediatrics with Infectious Diseases, Institute of Continuing Professional Education, Pirogov Russian National Research Medical University; 1, Ostrovityanov str., Moscow, 117997, Russian Federation; ORCID iD 0000-0001-6428-7424.
Irina V. Razheva — C. Sc. (Med.), Head of the Department of Pediatric Intensive Care and Emergency, Associate Professor of the Department of Anesthesiology and Emergency Department, M.F. Vladimirskiy Moscow Regional Research and Clinical Institute; 61/2, Shchepkin str., Moscow, 129110, Russian Federation; ORCID iD 0009-0007-5071-5652.
Anna S. Bevz — junior researcher at the Department of Pediatrics, M.F. Vladimirskiy Moscow Regional Research and Clinical Institute; 61/2, Shchepkin str., Moscow, 129110, Russian Federation; ORCID iD 0000-0002-4954-4872.
Svetlana V. Vorontsova — C. Sc. (Med.), radiologist of the Department of Radiation Diagnostics, M.F. Vladimirskiy Moscow Regional Research and Clinical Institute; 61/2, Shchepkin str., Moscow, 129110, Russian Federation; ORCID iD 0000-0003-3584-4345.
Contact information: Daria A. Kartashova, e-mail: snowwhiteforest@yandex.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 22.11.2023.
Revised 15.12.2023.
Accepted 16.01.2024.
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