Herpesvirus infections in ARVI episodes in children
DOI: 10.32364/2618-8430-2023-6-4-12
T.A. Ruzhentsova1,2, R.V. Popova3, A.A. Garbuzov1, E.K. Shushakova4, I.N. Khalyastov2,5, N.A. Meshkova6
1G.N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology of the Federal Service for the Oversight of Consumer Protection and Welfare, Moscow, Russian Federation
2Moscow Medical University "Reaviz", Moscow, Russian Federation
3Mytishchi Regional Clinical Hospital, Mytishchi, Russian Federation
4City Center for Medical Study LLC, Moscow, Russian Federation
5Rehabilitation Center of the Pension and Social Insurance Fund of the Russian Federation "Volginskii", Mashinostroitel, Russian Federation
6I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Aim: to evaluate the detection rate of the herpesvirus activity in children with acute respiratory viral infection (ARVI) signs for determination of the optimal treatment tactics.
Patients and Methods: the study included 1120 children aged 3 to 18 years (mean age 7.48±3.91 years) who were observed on an outpatient basis (n=650) or hospitalized (n=379) due to the lack of improvement on the 3rd day after the first ARVI symptoms onset (n=1029) or due to the detected complication (n=91). The herpesvirus DNA was detected in throat swabs by PCR. Enzyme immunoassay was used to evaluate the levels of IgG, IgM, and IgA antibodies.
Results: the presence of IgG antibodies to at least one of the herpes viruses was detected in 1097 (97.9%) of patients: in the children group over 6 years old in 723 (100%) patients. The presence of herpesvirus DNA in smears from the posterior pharyngeal wall and tonsils was detected in 234 (20.9%) children: 178 (15.9%) — isolated, 56 (5.0%) — in various combinations. IgM antibodies to Epstein-Barr virus and cytomegalovirus were detected in all cases in the herpesvirus DNA presence in the blood. The herpes simplex virus DNA has not been detected in any case. However, antibodies were detected in 63 (5.6%) children: IgA in 57 (5.1%) and IgM in 6 (0.5%) children.
Conclusions: in children with ARVI symptoms, signs of an active infection caused by one or another type of herpes were detected in 26.5% of cases, and in 5% — their combination. The high prevalence of the herpesvirus activity comparable with the detection rate of seasonal respiratory viral infections, along with the adverse effect of herpesvirus infection on the immune system with the severe somatic pathology probability, necessitates the use of a drug with a wide spectrum of antiviral action for the ARVI signs in children — inosine pranobex. In the presence of complications caused by herpesvirus, inosine pranobex does not cause negative trend of antibody activity indicators, inosine pranobex, Groprinosin®.
Keywords: HHV-6, human herpesvirus type 6, herpes simplex virus, Epstein-Barr virus, herpes, herpesvirus infection, herpes infection, ARVI, cytomegalovirus, inosine pranobex, Groprinosin.
For citation: Ruzhentsova T.A., Popova R.V., Garbuzov A.A., Shushakova E.K., Khalyastov I.N., Meshkova N.A. Herpesvirus infections in ARVI episodes in children. Russian Journal of Woman and Child Health. 2023;6(4):399–404 (in Russ.). DOI: 10.32364/2618-8430-2023-6-4-12.
About the authors:
Tatyana A. Ruzhentsova — Dr. Sc. (Med.), Deputy Director for Clinical Work, G.N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology of the Federal Service for the Oversight of Consumer Protection and Welfare; 10, Admiral Makarov str., Moscow, 125212, Russian Federation; Professor, Head of the Department of Internal Diseases, Moscow Medical University "Reaviz"; 29, Sokolovo-Meshcherskaya str., Moscow, 125466, Russian Federation; ORCID iD 0000-0002-6945-2019.
Raisa V. Popova — infectious diseases physician, Head of the Department of Children Infectious Diseases, Mytishchi Regional Clinical Hospital; 24, Kominterna str., Mytishchi, 141009, Russian Federation; ORCID iD 0000-0003-3324-3554.
Alexander A. Garbuzov — Junior Researcher of the Clinical Department, G.N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology of the Federal Service for the Oversight of Consumer Protection and Welfare; 10, Admiral Makarov str., Moscow, 125212, Russian Federation; ORCID iD 0000-0002-3378-8418.
Ekaterina K. Shushakova — Chief Medical Officer of City Center for Medical Study LLC; 1A, room IV, Severnoye Chertanovo microdistrict, Moscow, Russian Federation; ORCID iD0000-0003-2619-9110.
Igor N. Khalyastov — Dr. Sc. (Med.), Professor of the Department of Clinical Medicine of Postgraduate Education, Moscow Medical University "Reaviz"; 29, Sokolovo-Meshcherskaya str., Moscow, 125466, Russian Federation; Director of the Rehabilitation Center of the Pension and Social Insurance Fund of the Russian Federation "Volginskii"; Petushinsky district, Vladimir region, Mashinostroitel village, 601125, Russian Federation; ORCID iD 0000-0002-2541-4037.
Natalia A. Meshkova — 6th-year student of the N.F. Filatov Clinical Institute of Children's Health, I.M. Sechenov First Moscow State Medical University (Sechenov University); 8 Bldg. 2, Trubetskaya str., Moscow, 119991, Russian Federation; ORCID iD 0000-0003-3904-7108.
Contact information: Tatyana A. Ruzhentsova, e-mail: ruzhencova@gmail.com.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 18.09.2023.
Revised 09.10.2023.
Accepted 30.10.2023.
2. Боковой А.Г., Егоров А.И. Герпесвирусные инфекции у детей и родителей: Учебное пособие для студентов, врачей-педиатров, инфекционистов, иммунологов. М.: Центр стратегической конъюнктуры; 2014. [Bokovoy A.G., Yegorov A.I. Herpesvirus infections in children and parents: A textbook for students, pediatricians, infectious disease specialists, immunologists. M.: Tsentr strategicheskoy konyunktury; 2014 (in Russ.)].
3. Зуйкова И.Н., Шульженко А.Е., Щубелко Р.В. Коррекция цитокиновых нарушений у пациентов с хронической рецидивирующей герпесвирусной инфекцией. Фарматека. 2014;10:48–54. [Zuykova I.N., Shul'zhenko A.Ye., Shchubelko R.V. Correction of cytokine disorders in patients with chronic recurrent herpesvirus infection. Farmateka. 2014;10:48–54 (in Russ.)].
4. Исаков В.А., Архипова Е.И., Исаков Д.В. Герпесвирусные инфекции человека: руководство для врачей. 2-е изд., перераб. и дополн. СПб.: СпецЛит; 2013. [Isakov V.A., Arkhipova Ye.I., Isakov D.V. Human herpesvirus infections: a guide for doctors. 2nd ed., revised. SPb.: SpetsLit; 2013 (in Russ.)].
5. Руженцова Т.А. Гастроэнтерологические маски сердечно-сосудистой патологии. Экспериментальная и клиническая гастроэнтерология. 2016;130(6):114–117. [Ruzhentsova T.A. Gastroenterological masks for cardiovascular pathology. Eksperimental'naya i klinicheskaya gastroenterologiya. 2016;130(6):114–117 (in Russ.)].
6. Cairns D.M., Rouleau N., Parker R.N. et al. A 3D human brain-like tissue model of herpes-induced Alzheimer's disease. Sci Adv. 2020;6(19):eaay8828. DOI: 10.1126/sciadv.aay8828.
7. Шушакова Е.К., Руженцова Т.А., Николаева С.В. Механизмы влияния вирусов простого герпеса при неразвивающейся беременности. Инфекционные болезни. 2019;17(3):15–19. DOI: 10.20953/1729-9225-2019-3-15-19. [Shushakova Ye.K., Ruzhentsova T.A., Nikolayeva S.V. Mechanisms underlying the effects of herpes simplex virus on missed miscarriages. Infektsionnyye bolezni. 2019;17(3):15–19 (in Russ.)]. DOI: 10.20953/1729-9225-2019-3-15-19.
8. Шушакова Е.К., Мешкова Н.А., Хавкина Д.А. и др. Значение вируса простого герпеса в развитии бесплодия у семейных пар. Медицинский алфавит. 2021;32:16–19. DOI: 10.33667/2078-5631-2021-32-16-19. [Shushakova Ye.K., Meshkova N.A., Khavkina D.A. et al. The importance of the herpes simplex virus in the development of infertility in married couples. Meditsinskiy alfavit. 2021;32:16–19 (in Russ.)]. DOI: 10.33667/2078-5631-2021-32-16-19.
9. Dunmire S.K., Hogquist K.A., Balfour H.H. Infectious Mononucleosis. Curr Top Microbiol Immunol. 2015;390(Pt 1):211–240. DOI: 10.1007/978-3-319-22822-8_9.
10. Guerriero C., Moretta G., Bersani G. et al. Epstein-Barr virus-related cutaneous necrotizing vasculitis in a girl heterozygous for factor V Leiden. J Dermatol Case Rep. 2017;11(2):25–28. DOI: 10.3315/jdcr.2017.1245.
11. Мелехина Е.В., Николаева С.В., Солдатова Е.Ю. и др. Место инфекции, вызванной вирусом герпеса человека 6А/В, в детской популяции. РМЖ. 2019;10:17–21. [Melehina E.V., Nikolaeva S.V., Soldatova E.Ju. et al. Human herpesvirus 6 variant A/B infections in child population. RMJ. 2019;10:17–21 (in Russ.)].
12. Flamand L., Lautenschlager I., Krueger G., Ablashi D. Human herpesviruses HHV-6A, HHV-6B, and HHV-7. Diagnosis and clinical management. 3rd ed. USA: Elsevier, 2014.
13. Савенкова М.С., Исаева Е.И., Ветрова Е.Н. и др. Значение противовирусной терапии при респираторных инфекциях у детей: анализ клинико-лабораторного наблюдения. Вопросы практической педиатрии. 2022;17(6):45–54. DOI: 10.20953/1817-7646-2022-6-45-54. [Savenkova M.S., Isayeva Ye.I., Vetrova Ye.N. et al. The importance of antiviral therapy for respiratory infections in children: analysis of clinical and laboratory observation. Voprosy prakticheskoy pediatrii. 2022;17(6):45–54 (in Russ.)]. DOI: 10.20953/1817-7646-2022-6-45-54.
14. Исаков Д.В., Исаков В.А. Простой и опоясывающий герпес (клиника, лечение и профилактика): руководство для врачей. СПб.: СпецЛит; 2021. [Isakov D.V., Isakov V.A. Herpes simplex and herpes zoster (clinic, treatment and prevention): a guide for doctors. SPb.: SpetsLit; 2021 (in Russ.)].
15. Халиуллина С.В., Анохин В.А., Халиуллина К.Р., Покровская Е.М. Распространенность герпесвирусных инфекций у детей с гипертрофией глоточной миндалины. Рос вестн перинатол и педиатр. 2018;63(5):162–166. DOI: 10.21508/1027-4065-2018- 63-5-162-166. [Khaliullina S.V., Anokhin V.A., Khaliullina K.R., Pokrovskaya E.M. The Prevalence of Herpes Virus Infections in Children with Hypertrophy of the Glutal Mindaline. Ros Vestn Perinatol i Pediatr. 2018;63(5):162–166 (in Russ.)]. DOI: 10.21508/1027-4065-2018-63-5-162-166.
16. Руженцова Т.А., Плоскирева А.А., Алешина Н.И. и др. Возможности повышения эффективности терапии острых респираторных вирусных инфекций различной этиологии у детей. Инфекционные болезни. 2019;17(2):46–52. DOI: 10.20953/1729-9225-2019-2-46-52. [Ruzhentsova T.A., Ploskireva A.A., Aloshina N.I. Possibilities for increasing the effectiveness of therapy for acute respiratory viral infections of various etiologies in children. Infektsionnyye bolezni. 2019;17(2):46–52 (in Russ.)]. DOI: 10.20953/1729-9225-2019-2-46-52.
17. Колосова Н.Г., Шаталина С.И. Правильный алгоритм лечения ОРВИ в детском возрасте. Медицинский совет. 2017;19:158–161. DOI: 10.21518/2079-701X-2017-19-158-161. [Kolosova N.G., Shatalina S.I. Correct algorithm of arvi treatment in pediatric patients. Meditsinskiy sovet. 2017;(19):158–161 (in Russ.)]. DOI: 10.21518/2079-701X-2017-19-158-161.
18. Савенкова М.С., Исаева Е.И., Ветрова Е.Н. и др. Значение противовирусной терапии при респираторных инфекциях у детей: анализ клинико-лабораторного наблюдения. Вопросы практической педиатрии. 2022;17(6):45–54. DOI: 10.20953/1817-7646-2022-6-45-54. [Savenkova M.S., Isayeva Ye.I., Vetrova Ye.N. et al. The importance of antiviral therapy for respiratory infections in children: analysis of clinical and laboratory observation. Voprosy prakticheskoy pediatrii. 2022;17(6):45–54 (in Russ.)]. DOI: 10.20953/1817-7646-2022-6-45-54.
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