Children with recurrent respiratory infections: state of the art
DOI: 10.32364/2618-8430-2024-7-4-7
A.L. Zaplatnikov1, A.A. Girina2, E.I. Burtseva3, I.V. Lepiseva4, V.I. Svintsitskaya1, M.V. Leshik1
1Russian Medical Academy of Continuous Professional Education, Moscow,
Russian Federation
2Khanty-Mansiysk State Medical Academy, Khanty-Mansiysk, Russian Federation
3N.F. Gamaleya National Research Center of Epidemiology and Microbiology, Moscow,
Russian Federation
4N.I. Grigovich Children's Republican Hospital, Petrozavodsk, Russian Federation
We analyzed the literature data, and the paper presents our own study data on clarification of causes and initiating agents of pediatric recurrent respiratory infections (RRIs). The paper critically evaluates a conventional generalized approach to identify a group of "frequently ill children" and recommendations for their health improvement which are persistent on a practical level. It is emphasized that the term "frequently ill children" can disguise various abnormal conditions (i. e., allergic respiratory diseases and immunodeficiency et al.). In this regard, special attention has been given to timely clarification of causes of hypersusceptibility to infections in children. It is noted that positive perinatal and family RRI history, early socialization without appropriate preparation for initial visiting an arranged group, as well as improper feeding and daily routine, vaccination schedule delay, and unfavorable epidemiological and social conditions are the main risk factors for RRIs in children without serious health disorders. The paper evaluates tolerability, as well as preventive and therapeutic efficacy of bacterial lysates in children with RRIs. The reported study results demonstrate high safety and positive clinical, immunological and preventive efficiency of a polyvalent mechanical bacterial lysate in children with RRIs, recurrent and chronic respiratory diseases.
Keywords: immunoprophylaxis, acute respiratory infections, polyvalent mechanical bacterial lysate, recurrent respiratory infections, frequently ill children.
For citation: Zaplatnikov A.L., Girina A.A., Burtseva E.I., Lepiseva I.V., Svintsitskaya V.I., Leshik M.V. Children with recurrent respiratory infections: state of the art. Russian Journal of Woman and Child Health. 2024;7(4):334–341 (in Russ.). DOI: 10.32364/2618-8430-2024-7-4-7
About the authors:
Andrey L. Zaplatnikov — Dr. Sc. (Med.), professor, Head of the Prof. V.V. Gavryushov Department of Neonatology, Professor of the Acad. G.N. Speransky Department of Pediatrics, Russian Medical Academy of Continuous Professional Education; 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0000-0003-1303-8318
Asiya A. Girina — C. Sc. (Med.), associate professor of the Department of Pharmacology, Pediatrics and Infectious Diseases, Khanty-Mansiysk State Medical Academy; 40, Mira str., Khanty-Mansiysk, 628011, Russian Federation; ORCID iD 0000-0002-5281-1564
Elena I. Burtseva — Dr. Sc. (Med.), Head of the Laboratory of the Etiology and Epidemiology of Flu, D.I. Ivanovskiy Institute of Virology, N.F. Gamaleya National Research Center of Epidemiology and Microbiology, 16, Gamalei str., Moscow, 123098, Russian Federation; ORCID iD 0000-0003-2518-6801
Inga V. Lepiseva — Chief Physician, N.I. Grigovich Children's Republican Hospital; 58, Parkovaya str., Petrozavodsk, 185000, Russian Federation; ORCID iD 0000-0001-8989-6103
Victoria I. Svintsitskaya — C. Sc. (Med.), associate professor of the Acad. G.N. Speransky Department of Pediatrics, Russian Medical Academy of Continuous Professional Education; 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0000-0002-9272-2339
Maria V. Leshik — assistant of the Acad. G.N. Speransky Department of Pediatrics, Russian Medical Academy of Continuous Professional Education; 2/1, Barrikadnaya str., Moscow, 125993, Russian Federation; ORCID iD 0000-0002-9331-1419
Contact information: Andrey L. Zaplatnikov, e-mail: zaplatnikov@mail.ru
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
Conflict of interest: A.L. Zaplatnikov participated in an observational program to study clinical and preventive efficacy of Ismigen® (i. e., a polyvalent mechanical bacterial lysate) in children in routine pediatric practice. The remaining authors confirmed the absence of a conflict of interest and financial support to be reported.
Received 07.10.2024.
Revised 30.10.2024.
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