The topical antibiotic therapy in ENT practice

T.Yu. Vladimirova¹, N.V. Volov²

¹Samara State Medical University, Samara 

²«Outpatient centre No.1», Samara

Aim: to evaluate the clinical efficacy of framycetin solution for intranasal use in the complex therapy of acute bacterial rhinosinusitis (moderate severity).

Patients and Methods: a prospective randomized controlled study included 80 patients (mean age 33.13±8.5 years) with acute bacterial rhinosinusitis. The study participants were randomly assigned to two groups of 40 people: main and control. Patients in both groups received standard therapy in accordance with current clinical guidelines. In the main group, in addition, topical antibacterial therapy with framycetin in the dosage form of a nasal spray 1.25% was prescribed. The effectiveness of the therapy was assessed on the basis of anterior rhinoscopy data (the severity of mucosal edema and the presence of discharge on a 10-point visual analogue scale, VAS), the results of the SNOT-22 questionnaire, and a 10-point VAS for determining the severity of the condition. The examination was carried out at the primary outp atient appointment with an otorhinolaryngologist and again after 5 and 10 days.

Results: during the study in both groups, a stable positive trend of complaints and clinical status was demonstrated, which persisted throughout the entire follow-up period. According to the results of the study, on the 5th day of therapy, the frequency of complaints, which were marked as the main ones by the majority of patients, in the main group was lower than in the control group, more than 2 times, and the severity of almost all the main symptoms in this group was 3 times less than in the control group. The complete absence of complaints after treatment in the main group was noted by 15% of the examined, in the control group — by 10%. At the same time, only in the control group remained 5% of patients who assessed their condition as severe. According to the data of anterior rhinoscopy, upon re-examination on the 5th day, the swelling of the nasal mucosa in the main group corresponded to 5.20 10.45 points versus 8.0±0.65 points in the control group, the presence of discharge – 7.10±0.45 points and 7,4±0,5 points, respectively, on the 10th day – 3.6±0.3 points and 4,7±0,52 points, 2.8±0.3 points and 3,6±0,6 points, respectively.

Conclusion: a drug based on framycetin spray has a positive effect on the dynamics of the course of acute bacterial rhinosinusitis, improves overall well-being by restoring nasal breathing, which indicates the expediency of its use in the complex therapy of acute bacterial rhinosinusitis.

Keywords: rhinosinusitis, difficulty in nasal breathing, topical therapy, framycetin, spray, quality of life.

For citation: Vladimirova T.Yu., Volov N.V. The topical antibiotic therapy in ENT practice. RMJ. 2022;2:25–30.