Topical antimicrobial therapy for infectious and inflammatory diseases of the nose and paranasal sinuses

S.A. Karpischenko¹, A.A. Krivopalov¹, S.A. Eremin¹, P.A. Shamkina¹, A.V. Chufistova²

¹Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech, Saint Petersburg

²North-Western State Medical University named after I.I. Mechnikov, Saint Petersburg

Aim: to study the characteristics of sputtering and distribution of framycetin solutions (used for topical antibacterial therapy of infectious and inflammatory diseases in the nose and paranasal sinuses) in the infectious focus.

Patients and Methods: the study involved healthy volunteers. The following 2 medicinal products with different spraying device were chosen: TRAMICENT^® (Solopharm, Saint Petersburg) and ISOFRA^® (Laboratoires BOUCHARA-RECORDATI, France). High-speed photography and video recording methods were used in contrast lighting conditions for a comparative analysis of aerosol formation during spraying, and 70–120 ms and 180–190 ms after the start of spraying. To assess the distribution of framycetin solutions in the nasal cavity of the subjects, an imaging method was used with the qualitative criteria assessment using video endoscopy with photo and video fixation.

Results: the duration of TRAMICENT^® (Solopharm, Saint Petersburg) spray phase was stable due to the automatic sprayer mechanism and is 11–12 ms. The duration of ISOFRA^® (Laboratoires BOUCHARA-RECORDATI, France) spray phase varied significantly (from 32
to 47 ms) and directly depended on the fingers movement performing the spraying and the effort applied to the bottle. The cloud of TRAMICENT^® (Solopharm, Saint Petersburg) was visualized more compactly and retained saturation longer, while the cloud of ISOFRA^® (Laboratoires BOUCHARA-RECORDATI, France) was less saturated and occupied a larger area. The lifetime of aerosols in TRAMICENT^® (Solopharm, Saint Petersburg) was 230–278 ms (average 253 ms), which was significantly longer versus that of ISOFRA^® (Laboratoires BOUCHARA-RECORDATI, France) (122–220 ms), the average time was 166 ms. Spraying TRAMICENT^® (Solopharm, Saint Petersburg) promotes the entry of the antibacterial drug framycetin into the middle nasal passage, along the mucous membrane of the nasopharynx walls with the spread to the pharyngeal mouth of the Eustachian tube.

Conclusion: TRAMICENT^® (Solopharm, Saint Petersburg) in the experimental study demonstrated a high quality of aerosol spraying and distribution in the nasal cavity.

Keywords: otorhinolaryngology, spray, topical therapy, spraying and distribution of solutions, framycetin.

For citation: Karpischenko S.A., Krivopalov A.A., Eremin S.A. et al. Topical antimicrobial therapy for infectious and inflammatory diseases of the nose and paranasal sinuses. RMJ. 2020;5:26–30.