A comparative study of the efficacy of oxymetazoline - based intranasal vasoconstrictive sprays
Ulupov M.Yu.

The First St. Petersburg State medical University named after acad. I.P. Pavlov

Decongestants are the most common non-prescription drugs, which are widely used not only for the treatment of acute colds, but also for other acute and chronic diseases of ENT organs.
A comparative cross-sectional study was conducted to evaluate the effectiveness of nasal decongestants in the form of dosage sprays Oxifrin and Nazivin sensitiv.
Patients and methods. The study included 30 patients with chronic pathology of the nose and paranasal sinuses, who permanently used nasal decongestants for a long time. Each patient consequently used Nazivin sensitive and Oxifrin dosage sprays (each for 1 week) for 2 weeks instead of his usual vasoconstrictive drug. The effectiveness and comfort of the use of drugs was assessed both objectively - by the active anterior rhinomanometry method (in the first 10 patients), and subjectively - by questionnaire.
Results. Objective measurements of the vasoconstrictor effect with active anterior rhinomanometry did not reveal significant differences between Nazivin and Oxifrin. The total inspiratory flow was 536.0 ± 181.9 and 520 ± 225.2 ml / s, respectively (p = 0.67). The strength of Nazivin and Oxyfrin was evaluated by patients on a 10-point scale on average at 8 and 7.5 points, respectively (p = 0.388).
Conclusion. Dosage nasal vasoconstrictive spray Oxifrin is comparable in its effectiveness and comfort with the original drug Nazivin sensitive.

Key words: decongestants, active anterior rhinomanometry, questioning, Nazivin sensitive, Oxifrin
For citation: Ulupov M.Yu. A comparative study of the efficacy of oxymetazoline - based intranasal vasoconstrictive sprays. // RMJ. 2017. № 6. P. 400–404.