Expanding the range of effective topical treatment options for inflammatory diseases of the oropharynx

Expanding the range of effective topical treatment options for inflammatory diseases of the oropharynx

A.Yu. Ovchinnikov, N.A. Miroshnichenko, Yu.O. Nikolaeva, V.A. Yekaterinchev, I.V. Smirnov

Russian University of Medicine, Moscow

Aim: to assess the clinical efficacy, tolerability, and safety of an oral spray containing plant-derived biologically active polysaccharides from Solanum tuberosum shoots in the treatment of acute tonsillopharyngitis (ATP) of non-streptococcal etiology.

Patients and Methods: a simple open-label observational comparative study was performed. Based on randomization, patients were assigned to receive either the oral spray containing plant-derived biologically active polysaccharides from Solanum tuberosum shoots (main group, n=30) or a spray containing benzydamine (control group, n=30). Patients were allowed to discontinue treatment after day 5 if inflammatory symptoms had subsided. Clinical efficacy was evaluated by assessing the severity of sore throat using a visual analog scale (VAS) before and after the therapy initiation, performing mesopharyngoscopy and conducting cytomorphometric analysis. Safety assessment involved monitoring adverse events.

Results: the study group exhibited a more rapid reduction in the severity of sore throat as measured by VAS and showed greater improvement in mesopharyngoscopic picture. Cytomorphometric evaluation demonstrated a faster decrease in the average destructive index (ADI) of the epithelium in the main group versus the control group. Use of the studied oral spray resulted in a shorter treatment duration. No adverse events or allergic reactions were reported in the main group, whereas 8 patients (26.7%) in the control group experienced dryness of the throat.

Conclusion: the use of an oral spray containing plant-derived biologically active polysaccharides from Solanum tuberosum shoots during the acute phase of inflammatory damage to the respiratory mucosa facilitated more rapid and pronounced recovery of the pharyngeal mucosa affected by inflammation. This was substantiated by cytomorphometric data indicating a dynamic reduction in the epithelial ADI and other clinical improvements.

Keywords: acute tonsillopharyngitis, acute respiratory viral infections, acute tonsillopharyngitis, topical antiviral drugs, antiseptics, Panavir Inlight spray, polysaccharides of Solanum tuberosum plant, average destructive index of epithelium, cytomorphometry.

For citation: Ovchinnikov A.Yu., Miroshnichenko N.A., Nikolaeva Yu.O., Yekaterinchev V.A., Smirnov I.V. Expanding the range of effective topical treatment options for inflammatory diseases of the oropharynx. RMJ. 2025;1:49–54. DOI: 10.32364/2225-2282-2025-1-10