Infectious disease in upper respiratory tract disorders
Kryukov A.I., Turovskiy A.B., Kolbanova I.G., Kudryavtseva Yu.S.

L.I. Sverzhevskiy Scientific Research Institute for Ear, Nose, and Throat Diseases, Moscow

The paper discusses specific features of infectious diseases in patients with upper respiratory tract (UPT) disorders. It was demonstrated that UPT microbiomes have a dual role. First, they have positive effects on host ecosystem. Second, they colonize UPT mucosa with various microbes for a long time. In the course of colonization, microorganisms invade the host, cooperate and interact with the host, compete, and adapt to environmental factors. As a result of long-term adaptation, certain bacteria are able to form biofilms. These bacteria while being integrated into the biological community are characterized by very high (50-500-fold) antibacterial resistance. Pneumococci and P. aeruginosa form biofilms in chronic sinusitis and otitis, beta-hemolytic Streptococci form biofilms in chronic tonsillitis. Currently, it is generally accepted that biofilms are responsible for ineffective antibacterial therapy for pyogenic inflammatory conditions in a number of patients. The authors recommend macrolides, i.e., roxithromycin, for acute UPT infections.

Key words: acute infections, upper respiratory tract, macrolides, roxithromycin , biofilms, bacterial colony, microbiome, resistance, antibacterial therapy.

For citation: Kryukov A.I., Turovskiy A.B., Kolbanova I.G., Kudryavtseva Yu.S. Infectious disease in upper respiratory tract disorders // RMJ. 2016. № 21. P. –1402.