Patterns of pathogenetic antibacterial therapy concerning ENT organs in modern conditions

Patterns of pathogenetic antibacterial therapy concerning ENT organs in modern conditions

S.A. Eremin, V.V. Dvorianchikov, S.V. Ryazantsev, S.S. Pavlova, S.I. Sitnikov

Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech, St.-Petersburg 

Inflammatory diseases of the ENT organs are the most common diseases in the world. In most cases, there is a primary viral infection that provokes pathology. However, despite the tendency to self-resolution and the absence of the need in antibiotics, the latter are widely used in the therapy of ENT organs. The article summarizes the data of modern Russian and foreign literature on the available possibilities in antimicrobial therapy of the upper respiratory tract and ear, as well as its efficacy. Attention is focused on the problem of the antibiotic resistance increase, methods of rational use concerning antibacterial drugs at the present stage, as well as aspects that prevent the correct treatment from being prescribed. It has been shown that the combination of amoxicillin with clavulanic acid is effective in the treatment of infections caused not only by monocultures of virulent bacterial strains, but also by their associations, which is especially importan t in the treatment of chronic diseases and their prevention. In conditions of increasing antibiotic resistance to penicillin, the group of beta-lactam antibiotics and macrolides, the combination of amoxicillin with clavulanic acid retains one of the highest efficiency indicators, which has not significantly changed over time.

Keywords: upper respiratory tract infections, antibiotic resistance, bacterial agents, systemic antibacterial drugs, amoxicillin, clavulanic acid.

For citation: Eremin S.A., Dvorianchikov V.V., Ryazantsev S.V. et al. Patterns of pathogenetic antibacterial therapy concerning ENT organs in modern conditions. RMJ. 2023;1:32–37.