The place of topical mucoactive drugs in the comprehensive treatment of acute paranasal sinusitis
DOI: 10.32364/2587-6821-2021-5-7-508-512
The place of topical mucoactive drugs in the comprehensive treatment of acute paranasal sinusitis
T.A. Mashkova, A.B. Maltsev
Voronezh State Medical University named after N.N. Burdenko, Voronezh, Russian Federation
Rhinology rapid development, the emergence of new and improvement of already known methods of diagnosis and treatment of paranasal sinuses (PNS) inflammatory diseases almost did not affect the prevalence growth rate of this pathology. Surgical interventions did not contribute to reducing the frequency of recurrence and chronicity of paranasal sinusitis, while the need for drug therapy is steadily increasing. The availability of the mucous membrane for drug exposure, its continuity in both the upper and lower respiratory tract, high reflexogenic response allow topically stimulating secretory activity, causing dehydration of all glandular components of the mucous membrane. The article presents the experience of using the drug, an extract of Cyclamen europaeum, in the treatment of acute rhinosinusitis. Clinical examples show the efficacy of its use both as monotherapy and in combination with systemic antibiotics. The significant drainage effect of the drug allows avoiding invasive methods of PNS lavage (puncture, intubation, etc.) in the complex therapy of this pathology and reducing the treatment duration by 3–4 days compared to the control group. Therefore, it can be recommended for wider use in the treatment of catarrhal processes and purulent inflammation of the nasal mucosa and PNS.
Keywords: acute rhinosinusitis, topical therapy, plant extracts, European cyclamen, efficacy, computed tomography, pneumatization, paranasal sinuses.
For citation: Mashkova T.A., Maltsev A.B. The place of topical mucoactive drugs in the comprehensive treatment of acute paranasal sinusitis. Russian Medical Inquiry. 2021;5(7):508–512 (in Russ.). DOI: 10.32364/2587-6821-2021-5-7-508-512.
2. Fokkens W.J., Lund V.J., Hopkins C. et al. European Position Paper on Rhinosinusitis and Nasal Polyps 2020. Rhinology. 2020;58(29):1–464. DOI: 10.4193/Rhin20.600.
3. Jaume F., Quinto L., Alobid I., Mullol J. Overuse of diagnostic tools and medications in acute rhinosinusitis in Spain: a population-based study (the PROSINUS study). BMJ Open. 2018;8(1):e018788. DOI: 10.1136/bmjopen-2017-018788.
4. Piskunov S.Z., Dolzhikov A.A., Kalinkin A.A. Experimental morphological study on sinuforte effects on the sinonasal mucosa. Russian Rhinology. 2009;4(17):7–13 (in Russ.).
5. Mashkova T.A., Matveeva V.N. Objective assessment of the efficiency of secretolytic, secreto-stimulating therapy in the complex treatment of acute rhinosinusitis. Rossiiskaya otorinolaringologiya. 2007;5(30):109–112 (in Russ.).
6. Ovchinnikov A.Yu., Edzhe M.A. Acute bacterial rhinosinusitis. do we always need antibiotics? Farmateka. 2020;14(27):87–92 (in Russ.). DOI: 10.18565/pharmateca.2020.14.87-92.
7. Fernandez-Campos F., Clares B., Rodriguez-Lagunas M.J. et al. Ex-Vivo and In-Vivo assessment of Cyclamen europaeum extract after nasal administration. Pharmaceutics. 2019;11(9):426. DOI: 10.3390/pharmaceutics11090426.
8. Shilenkova V.V., Shilenkov K.A. EPOS-2020. What’s new? Russian Rhinology. 2020;28(2):94–100 (in Russ.). DOI: 10.17116/rosrino20202802194.
9. Expert Council resolution "updating clinical recommendations for acute rhinosinusitis and their adaptation to EPOS 2020». Russian Rhinology. 2020;28(4):257–265 (in Russ.). DOI: 10.17116/rosrino202028041257.
10. Palchun V.T. Otorhinolaryngology: National leadership. M.: GEOTAR-Media; 2020 (in Russ.).
11. Yanov Yu.K., Ryazantsev S.V., Timchuk I.E. Efficacy of sinuforte monotherapy in patients with acute and chronic rhinosinusitis at an exacerbation stage. Vestnik otorinolaringologii. 2007;4:49–51 (in Russ.).
12. Jurkiewicz D., Hassmann-Poznanska E., Kazmierczak H. et al. Lyophilized Cyclamen europaeum tuber extract in the treatment of rhinosinusitis. Otolaryngologia Polska. 2016;70(1):1–9. DOI: 10.5604/00306657.1195609.
13. Mashkova T.A., Isaev A.V., Malcev A.B. Possibilities of secretolytic and secret-stimulating therapy of exudative rhinosinusitis. Proceedings of Voronezh State University. Chemistry. Biology. Pharmacy. 2018;3:239–243 (in Russ.).
14. Mashkova T.A., Matveeva V.N., Panchenko I.G. Comparative characteristic of different methods of conservative treatment of exudative rhinosinusitis. Vestnik otorinolaringologii. 2010;(5):13–14 (in Russ.).
15. Ponikau J.U., Hamilos D.L., Barreto A. et al. An exploratory trial of Cyclamen europaeum extract for acute rhinosinusitis. Laryngoscope. 2012;122(9):1887–1892. DOI: 10.1002/lary.23366.
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