On the issue of differential diagnosis of true pemphigus complicated by candidal infection in neoplastic diseases
DOI: 10.32364/2587-6821-2025-9-7-
On the issue of differential diagnosis of true pemphigus complicated by candidal infection in neoplastic diseases
O.V. Karzanov1, A.G. Kupriyanova1, I.A. Baranov1, V.Yu. Rudakova2, V.O. Kornyushenko1, A.I. Zotov1, A.V. Molochkov1
1M.F. Vladimirskiy Moscow Regional Research and Clinical Institute, Moscow, Russian Federation
2Federal State University of Education, Moscow, Russian Federation
ABSTRACT
The term "acantholytic pemphigus" encompasses a group of heterogeneous, chronic, autoimmune bullous dermatoses characterized by potential involvement of both the skin and mucous membranes. The differential diagnosis between disease variants such as pemphigus vulgaris (PV) and paraneoplastic pemphigus (PNP) commonly presents considerable challenges. At present, the principal modality for the verification of acantholytic pemphigus, in conjunction with morphological assessment, involves immunomorphological techniques — including, most notably, direct immunofluorescence — which enable the detection of immune complex deposition in various layers of the skin. This article examines the role of immunomorphological research in the differential diagnosis of PV and PNP. Based on the clinical case presented, it is posited that PV may arise in the context of a neoplastic process independently of paraneoplastic syndrome.
Keywords: true pemphigus, paraneoplastic pemphigus, candidal infection, immunomorphological research.
For citation: Karzanov O.V., Kupriyanova A.G., Baranov I.A., Rudakova V.Yu., Kornyushenko V.O., Zotov A.I., Molochkov A.V. On the issue of differential diagnosis of true pemphigus complicated by candidal infection in neoplastic diseases. Russian Medical Inquiry. 2025;9(7) (in Russ.). DOI: 10.32364/2587-6821-2025-9-7-ABOUT THE AUTHORS:
Oleg V. Karzanov — C. Sc. (Med.), Senior Researcher at the Department of Dermatovenerology, M.F. Vladimirskiy Moscow Regional Research and Clinical Institute; 61/2, Shchepkin str., Moscow, 129110, Russian Federation; ORCID iD 0000-0002-2461-546X
Anna G. Kupriyanova — C. Sc. (Med.), Leading Researcher at the Department of Morphological Diagnostics and the Laboratory of Dermatooncology, M.F. Vladimirskiy Moscow Regional Research and Clinical Institute; 61/2, Shchepkin str., Moscow, 129110, Russian Federation; ORCID iD 0000-0002-1096-5717
Ilya A. Baranov — Junior Researcher at the Department of Dermatovenerology, M.F. Vladimirskiy Moscow Regional Research and Clinical Institute; 61/2, Shchepkin str., Moscow, 129110, Russian Federation; ORCID iD 0009-0006-1225-0420
Violetta Yu. Rudakova — Resident of the Course of Dermatovenerology at the Department of Pediatric Diseases, Federal State University of Education; 10A build. 2, Radio str., Moscow, 105005, Russian Federation; ORCID iD 0009-0001-9393-7972
Vladislava O. Kornyushenko — Junior Researcher at the Department of Dermatovenerology, M.F. Vladimirskiy Moscow Regional Research and Clinical Institute; 61/2, Shchepkin str., Moscow, 129110, Russian Federation; ORCID iD 0009-0009-1989-2364
Alexander I. Zotov — medical physician of the Department of Dermatovenerology, M.F. Vladimirskiy Moscow Regional Research and Clinical Institute; 61/2, Shchepkin str., Moscow, 129110, Russian Federation; ORCID iD 0009-0007-9139-340X
Anton V. Molochkov — Dr. Sc. (Med.), Professor, Head of the Department of Dermatovenerology and Dermatooncology of the Faculty of Advanced Medical Training, M.F. Vladimirskiy Moscow Regional Research and Clinical Institute; 61/2, Shchepkin str., Moscow, 129110, Russian Federation; ORCID iD 0000-0002-6456-998X
Contact information: Ilya A. Baranov, e-mail: ilya.baranov98@inbox.ru
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interest.
Received 29.01.2025.
Revised 21.02.2025.
Accepted 18.03.2025.
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