Possibilities of proton therapy. Clinical aspects
Vorobiev N.A.^1-3, Mikhailov A.V.¹, Smirnova E.V.^1,3, Gutsalo Yu.V.¹, Martynova N.I.<sup>1

1</sup> Medical and Diagnostic Center of International Institute of Biological Systems named after Berezin Sergei, St. Petersburg
² Saint Petersburg State University
³ North Western State Medical University named after I.I. Mechnikov, St. Petersburg

The article presents the possibilities of proton therapy as a new method of treating malignant tumors, which has certain advantages over standard photon radiation therapy. This is due to the possibility of creating the maximum dose of radiation in the target area without exceeding the tolerated dosages for normal tissues, even if the target is close to the critical structures of the body. A higher dose leads, respectively, to a greater probability of death of cancer cells.
Currently, there is an active accumulation of experience in the clinical use of proton therapy. The presented studies show the potential advantage of proton therapy in the treatment of CNS tumors, chord and chondrosarcoma of the skull and skeleton base, head and neck tumors, malignant tumors in children. The role of protons in cancer of the rectum, stomach, prostate, pancreas is actively studied. The results obtained should help to identify groups of patients for whom proton therapy will be crucial in improving disease control, overall survival and maintaining quality of life.

Key words: proton therapy, chordoma, chondrosarcoma, malignant tumors in children, radioinduced tumors.
For citation: Vorobiev N.A., Mikhailov A.V., Smirnova E.V. et al. Possibilities of proton therapy. Clinical aspects // RMJ. 2017. № 16. P. 1175–1180.