DOI: 10.32364/2618-8430-2020-3-2-95-99
Trousseau syndrome and ovarian cancer
E.F. Kalinkina1, N.P. Sluvko2, O.V. Kondrat’eva1, D.G. Tarasov1,3
1Federal Center for Cardiovascular Surgery (Astrakhan), Astrakhan, Russian Federation
2Regional Oncological Dispensary, Astrakhan, Russian Federation
3Astrakhan State Medical University, Astrakhan, Russian Federation
Migratory thrombophlebitis is a rare paraneoplastic syndrome occurred in malignancies. The association between migratory thrombophlebitis and malignancy is known as Trousseau syndrome. Thrombotic complications preceding malignancy manifestation are referred to as thrombotic mask. This paper describes successful surgical outcome of ovarian cancer associated with Trousseau syndrome. The first manifestations of this syndrome were acute proximal thrombosis in the left popliteal and left femoral vein, spontaneous arterial thrombosis, and numerous intracranial thromboses that have resulted in myocardial infarction and ischemic stroke. Later, the woman was diagnosed with ovarian cancer (T1aN0M0). All paraneoplastic signs have disappeared after a surgery for ovarian cancer. Congenital thrombophilia was an additional risk factor for thrombosis. The woman was provided with surgical, anesthetic, and intensive medical care which have improved the quality of life, increased life expectancy , and returned workability.
Keywords: ovarian cancer, paraneoplastic syndrome, Trousseau syndrome, thrombotic complications, hemostasis disorders.
For citation: Kalinkina E.F., Sluvko N.P., Kondrat’eva O.V., Tarasov D.G. Trousseau syndrome and ovarian cancer. Russian Journal of Woman and Child Health. 2020;3(2):95–99. DOI: 10.32364/2618-8430-2020-3-2-95-99.
2. Evans T.R., Mansi J.L., Bevan D.H. Trousseau’s syndrome in association with ovarian carcinoma. Cancer.1996;77(12):2544–2549. DOI: 10.1002/ (SICI) 1097–0142 (19960615) 77:12<2544:: AID-CNCR18>3.0.CO;2-S.
3. Vorobev A.V., Makatsaria A.D., Chabrov A.M., Savchenko A.A. Pathogenesis of Trousseau’s syndrome. Journal of obstetrics and women’s diseases. 2015;64(4):85–94 (in Russ.). DOI: 10.17816/JOWD64485-94.
4. Zuffa M. Paraneoplastický tromboembolický syndróm ako prvý príznak zhubného ochorenia. [Paraneoplastic thromboembolic syndrome as the first sign of a malignant disease]. Vnitr Lek. 2010;56(1):49–52.
5. Lyman G.H. Venous thromboembolism in the patient with cancer: focus on burden of disease and benefits of thromboprophylaxis. Cancer. 2011;117(7):1334–1349. DOI: 10.1002/cncr.25714.
6. Watanabe Y., Matsunuma K., Kaneda T. A case of successful anesthetic management in a patient with Trousseau’s syndrome who underwent surgery for malignant ovarian tumor. JA Clin Rep. 2020;6(1):32. DOI: 10.1186/s40981–020–00339–2.
7. Kim J., Kim H.J., Park S. et al. Predictive Factors of Deep Vein Thrombosis in Gynecologic Cancer Survivors with Lower Extremity Edema: A Single-Center and Retrospective Study. Healthcare (Basel). 2020;8(1):48. DOI: 10.3390/healthcare8010048.
8. Chystyk T. Rejuvenation of myocardial infarctions and strokes: modern methods of prevention. Arterial’naya gipertenziya. 2016:4 (48):57–62 (in Russ.). DOI: 10.22141/2224-1485.4.48.2016.76997.
9. Lazutina O.M., Markova L.I., Belaia O.L. et al. Miocardial infarction in colon cancer. Klin Med (Mosk). 2013;91(4):70–73 (in Russ.).
10. Cohn P.F., Braunwald E. Chronic ischemic heart disease. In: Braunwald E., ed. Heart disease. 2-nd ed. Philadelphia. Saunders; 1984.
11. Takano H., Nakajima K., Nagayoshi Y. et al. Clinical associations of Trousseau’s syndrome associated with cerebral infarction and ovarian cancer. J Gynecol Oncol. 2018;29(5): e67. DOI: 10.3802/jgo.2018.29.e67.
12. Nikitenko P.S., Miklyaeva P.V., Nikitenko S.V. et al. Ischemic stroke in a patient with gastric adenocarcinoma. The Siberian Medical Journal (Irkutsk).2016;6:33–35 (in Russ.).
13. Dvoretsky L.I., Dyadkov I.N., Stepanchenko A.P., Dubrovskaya N.V. Venous thromboembolism as the first manifestation of disseminated malignancy (Trusso’s syndrome). Bulletin of Siberian Medicine. 2019;18(3):232–237 (in Russ.).
14. Varki A. Trousseau’s syndrome: multiple definitions and multiple mechanisms. Blood. 2007;110(6):1723–1729. DOI: 10.1182/blood-2006–10–053736
15. Chatterjee M., Hurley L.C., Tainsky M.A. Paraneoplastic antigens as biomarkers for early diagnosis of ovarian cancer. Gynecol Oncol Rep. 2017;21:37–44. DOI: 10.1016/j.gore.2017.06.006.
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