Results of application of heparin-containing lubricant in the treatment of dry eye syndrome
Egorov E.A., Romanova Т.B., Oganezova J.G., Tibieva Z.U., Dzukaeva D.S.

Russian National Research Medical University named after N.I. Pirogov, Moscow

The aim: to study the action of the ophthalmic lubricant PARIN-POS ® in patients with the dry eye syndrome (DES).
Patients and Methods: The study included 30 patients (60 eyes) aged 22 to 88 years, 27 women and 3 men, with mild and moderate DES, developed against a background of various eye diseases and conditions. All patients underwent outpatient examination and follow-up. The exception was one patient, who, due to a difficult general condition, received treatment and was observed at home. The following diagnostic methods were used in the work: collection of complaints and anamnesis, autorefractometry, study of visual acuity with correction, tonometry, fluorescein biomicroscopy, determination of tear film rupture time, Schirmer test. The patients were examined by a unified method before the drug administration, on the seventh (7 ± 2 days) and 28-th (2 ± 2) day from the beginning of the drug application. All patients were assigned to put a strip of 0.5-1 cm of the PARIN-POS ® ointment in the conjunctival cavity once a day at night as a supplement to the already conducted treatment of the DES with the artificial tear drops. 
Results: 26 patients (52 eyes) underwent a complete course of examinations and treatment, one patient was treated at home, including putting the ointment into the conjunctival cavity once a day and lubricating the skin around the eyes 2 times a day.
Three patients (10%) failed to use the drug because of the increased symptoms of dryness and irritation of the eyes and eyelids.
Conclusions: PARIN-POS ® ointment is well tolerated by patients: a positive effect was achieved in 90% of cases; the subjective sensations weakened or vanished in the all patients. By the end of the observation period, the conjunctival hyperemia became less pronounced, the staining of the cornea and conjunctiva decreased to a great extent or disappeared; there was a noticeable tendency of strengthening the tear film and increasing the tear production. The ointment has a positive effect on the skin of the eyelids and face, removing the feeling of irritation and dryness, promotes the healing of skin cracks in the corners of the eyes.

Key words: dry eye syndrome, tear film, mucinous layer, artificial tear, sodium hyaluronate, heparin, bioadhesion, eye ointment.
For citation: Egorov E.A., Romanova Т.B., Oganezova J.G. et al. Results of application of heparin-containing lubricant in the treatment of dry eye syndrome // RMJ. Clinical ophthalmology. 2017. № 3. P. 135–140.