The first experience with brolucizumab for neovascular age-related macular degeneration
DOI: 10.32364/2311-7729-2022-22-2-108-115
A.N. Kulikov, D.S. Maltsev, A.Yu. Malafeeva, S.M. Perminova, V.R. Zhalimova,
A.S. Vasiliev, A.A. Kazak
S.M. Kirov Military Medical Academy, St. Petersburg, Russian Federation
Aim: to assess the efficacy and safety of brolucizumab in Russian patients with neovascular age-related macular degeneration (nAMD).
Patients and Methods: this study enrolled 47 patients with nAMD divided into two groups. Group 1 included 13 treatment-naïve patients/13 eyes (12 men and 1 woman, mean age 72.4±9.5 years, mean best-corrected visual acuity (BCVA) 0.43±0.32). Group 2 included 34 patients having active nAMD despite ongoing treatment/34 eyes (25 men and 9 women, mean age 74.1±8.0 years, mean BCVA 0.46±0.25). All patients received at least two intravitreal injections of brolucizumab (in total, 137 injections) with a 1-month interval. Patients were examined one month after the 2nd injections. BCVA, central macular thickness (CMT), macular volume (MV), sub/intraretinal fluid, and adverse events were evaluated.
Results: in group 1, a significant increase in BCVA from 34.9±6.6 letters to 44.1±4.2 letters (p=0.02) was reported. Meanwhile, in group 2, BCVA remained unchanged (35.0±3.5 letters before treatment vs. 33.8±3.7 letters after treatment, p>0.05). In group 1, CMT and MV significantly reduced, while in group 2, only MV significantly reduced (p<0.05). A significant reduction in the cumulative rate of sub/intraretinal fluid was detected in both groups (p<0.05).
Conclusions: treatment-naïve patients who received brolucizumab demonstrated a significant improvement of anatomical and functional parameters. Meanwhile, patients with active nAMD despite ongoing treatment who received brolucizumab demonstrated a significant reduction in disease activity and tendency to the improvement of anatomical (but not functional) parameters.
Keywords: age-related macular degeneration, brolucizumab, optical coherence tomography, anti-VEGF therapy.
For citation: Kulikov A.N., Maltsev D.S., Malafeeva A.Yu. et al. The first experience with brolucizumab for neovascular age-related macular degeneration. Russian Journal of Clinical Ophthalmology. 2022;22(2):108–115 (in Russ.). DOI: 10.32364/2311-7729-2022-22-2-108-115.
About the authors:
Aleksey N. Kulikov — Dr. Sc. (Med.), Professor, Head of the Department of Ophthalmology, S.M. Kirov Military Medical Academy; 21, Botkinskaya str., St. Petersburg, 194044, Russian Federation; ORCID iD 0000-0002-5274-6993.
Dmitriy S. Maltsev — Dr. Sc. (Med.), Head of the Department of Laser Surgery of the Clinics of Ophthalmology, S.M. Kirov Military Medical Academy; 21, Botkinskaya str., St. Petersburg, 194044, Russian Federation; ORCID iD 0000-0001-6598-3982.
Anna Yu. Malafeeva — Head of Department of Vitreoretinal Surgery of the Clinics of Ophthalmology, S.M. Kirov Military Medical Academy; 21, Botkinskaya str., St. Petersburg, 194044, Russian Federation; ORCID iD 0000-0001-9957-1804.
Sof’ya M. Perminova — clinical resident of the Clinics of Ophthalmology, S.M. Kirov Military Medical Academy; 21, Botkinskaya str., St. Petersburg, 194044, Russian Federation; ORCID iD 0000-0001-5697-5630.
Valeria P. Zhalimova — ophthalmologist of the Clinics of Ophthalmology, S.M. Kirov Military Medical Academy; 21, Botkinskaya str., St. Petersburg, 194044, Russian Federation; ORCID iD 0000-0001-8024-0300.
Aleksandr S. Vasile’v — ophthalmologist of the Clinics of Ophthalmology, S.M. Kirov Military Medical Academy; 21, Botkinskaya str., St. Petersburg, 194044, Russian Federation; ORCID iD 0000-0002-0635-4438.
Alina A. Kazak — clinical resident of the Clinics of Ophthalmology, S.M. Kirov Military Medical Academy; 21, Botkinskaya str., St. Petersburg, 194044, Russian Federation; ORCID iD 0000-0002-6855-2384.
Contact information: Dmitriy S. Maltsev, e-mail: glaz.med@yandex.ru.
Financial Disclosure: no authors have a financial or property interest in any material or method mentioned.
There is no conflict of interests.
Received 15.02.2022.
Revised 15.03.2022.
Accepted 07.04.2022.
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