Optimization of tear substitute drugs choice in dry eye syndrome therapy
Koroleva I.A.¹, Oganezova J.G.², Egorov E.A.<sup>2

1</sup> Municipal Clinical Hospital 15 named after O.M. Filatov, Moscow
² Russian National Research Medical University named after N.I. Pirogov, Moscow

Dry eye is a common disorder in routine ophthalmological practice, and a better understanding of the complex pathophysiology is leading to improved treatment. Artificial tear preparations are important in the management of dry eye syndrome. They have been designed with a focus on physical properties relating to wetting of the ocular surface and usually contain natural polymers, such as sodium hyaluronate (SH). SH increases the stability of the precorneal tear film, which protects the ocular surface from environmental agents, and it has water retentive properties, which improve ocular surface wettability. Several studies have demonstrated the efficacy of sodium hyaluronate in the treatment of dry eye syndrome. In most severe cases, treatment with non‐preserved eye drops is mandatory to avoid the toxicity of preservative when using the eye drops at frequent intervals. The efficacy of non‐preserved artificial tears Hylo-Comod, Hylomax-Comod, Hylosar-Comod and Hyloparin-Comod is described. 

Key words: dry eye syndrome, tear film, artificial tears, sodium hyaluronate. 

For citation: Koroleva I.A., Oganezova J.G., Egorov E.A. Optimization of tear substitute drugs choice in dry eye syndrome therapy // RMJ. Clinical ophthalmology. 2016. № 4. P. 227–231.